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肠道病毒复制：逆流而上。

Enterovirus replication: go with the (counter)flow.

机构信息

Department of Veterinary Medicine and Virginia-Maryland Regional College of Veterinary, Medicine, University of Maryland, College Park, MD, USA.

Department of Veterinary Medicine and Virginia-Maryland Regional College of Veterinary, Medicine, University of Maryland, College Park, MD, USA.

出版信息

Trends Microbiol. 2015 Apr;23(4):183-4. doi: 10.1016/j.tim.2015.02.008. Epub 2015 Mar 3.

DOI:10.1016/j.tim.2015.02.008
PMID:25748799
Abstract

All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintain their unique lipid composition is largely unknown. Two recent studies reveal that enteroviruses harness the PI4P-cholestrol exchange cycle driven by OSBP1 protein and PI4 kinase(s), and that blocking the dynamic lipid flow inhibits virus replication.

摘要

所有 (+)RNA 病毒都在独特的膜结构域中进行复制；然而，它们如何诱导和维持其独特的脂质组成在很大程度上仍是未知的。最近的两项研究揭示了肠道病毒利用 OSBP1 蛋白和 PI4 激酶驱动的 PI4P-胆固醇交换循环，并且阻断动态脂质流可抑制病毒复制。

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