Sun Tian, Wang Xian, Xu Hao
Graduate School, Beijing University of Chinese Medicine, Beijing, 100029, China.
Chin J Integr Med. 2015 Jul;21(7):542-50. doi: 10.1007/s11655-015-2070-0. Epub 2015 Mar 6.
To evaluate the efficacy and safety of Ginkgo Biloba extract for patients with angina pectoris according to the available evidence.
Electronic databases were searched for all of the randomized controlled trials (RCTs) of angina pectoris treatments with Ginkgo Biloba extract, either alone or combined with routine Western medicine (RWM), and controlled by untreated, placebo, Chinese patent medicine, or RWM treatment. The RCTs were retrieved from the following electronic databases: PubMed/MEDLINE, ProQuest Health and Medical Complete, Springer, Elsevier, and ProQuest Dissertations and Theses, Wanfang Data, China National Knowledge Infrastructure (CNKI), VIP database, China Biology Medicine (CBM), Chinese Medical Citation Index (CMCI), from the earliest database records to December 2012. No language restriction was applied. Study selection, data extraction, quality assessment, and data analyses were conducted according to the Cochrane standards. RevMan 5.1.0 provided by Cochrane Collaboration The data were analysed by using.
A total of 23 RCTs (involving 2,529 patients) were included and the methodological quality was evaluated as generally low. Ginkgo Biloba extract with RWM was more effective in angina relief and electrocardiogram improvement than RWM alone. Reported adverse events included epigastric discomfort, nausea, gastrointestinal reaction, and bitter taste.
Ginkgo Biloba extract may have beneficial effects on patients with angina pectoris, although the low quality of existing trials makes it difficult to draw a satisfactory conclusion. More rigorous, high quality clinical trials are needed to provide conclusive evidence.
根据现有证据评估银杏叶提取物对心绞痛患者的疗效和安全性。
检索电子数据库，查找所有使用银杏叶提取物单独或联合常规西药治疗心绞痛的随机对照试验（RCT），对照为未治疗、安慰剂、中成药或常规西药治疗。从以下电子数据库检索RCT：PubMed/MEDLINE、ProQuest健康与医学全文数据库、施普林格、爱思唯尔、ProQuest学位论文数据库、万方数据、中国知网、维普数据库、中国生物医学文献数据库（CBM）、中国医学引文索引（CMCI），检索最早的数据库记录至2012年12月。不设语言限制。根据Cochrane标准进行研究选择、数据提取、质量评估和数据分析。使用Cochrane协作网提供的RevMan 5.1.0对数据进行分析。
共纳入23项RCT（涉及2529例患者），方法学质量总体评估为低。银杏叶提取物联合常规西药在缓解心绞痛和改善心电图方面比单用常规西药更有效。报告的不良事件包括上腹部不适、恶心、胃肠道反应和口苦。
银杏叶提取物可能对心绞痛患者有益，尽管现有试验质量低，难以得出令人满意的结论。需要更严格、高质量的临床试验来提供确凿证据。
