Pan Weidong, Zhu Wei, Gao Qi, Liao Weilong, Gao Penglin, Liu Te
Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Neurology, Gongli Hospital, The Second Military Medical University, Shanghai, China.
Evid Based Complement Alternat Med. 2018 Apr 26;2018:6184260. doi: 10.1155/2018/6184260. eCollection 2018.
Observe the effect of the Chinese herbal extracts, Yin-Xing-Tong-Zhi, in tablet form, on improving vascular cognitive impairment no dementia (VCIND).
Sixty-eight patients with VCIND were divided randomly into treatment and placebo groups with oral administration of Yin-Xing-Tong-Zhi tablets (YXTZTs) or placebo, respectively, for 24 weeks. Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) subscale score, MMSE score, Clinician's Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus) score, expression of interleukin- (IL-) 6, IL-8, and tumor necrosis factor- (TNF-) in serum, and variation of blood-lipid levels were evaluated at different time points.
At weeks 12 and 24, the scores for the ADAS-Cog, CIBIC-Plus, and MMSE of the treatment group were significantly lower than those of the control group ( < 0.05). All clinical scales at week 24 of the control group were significantly different from those before treatment ( < 0.05). Expression of IL-6, IL-8, and TNF- in the two groups was reduced significantly with variation of the clinical scales of cognitive impairment.
YXTZTs may delay the development of cognitive impairment in VCIND patients by modulating expression of VCIND-associated proinflammatory factors.
观察中药提取物银杏酮酯片对改善非痴呆型血管性认知障碍（VCIND）的作用。
将68例VCIND患者随机分为治疗组和安慰剂组，分别口服银杏酮酯片（YXTZTs）或安慰剂，疗程24周。在不同时间点评估阿尔茨海默病评估量表认知分量表（ADAS-Cog）评分、简易精神状态检查表（MMSE）评分、基于临床医生访谈的变化印象加照顾者意见（CIBIC-Plus）评分、血清中白细胞介素-（IL-）6、IL-8和肿瘤坏死因子-（TNF-）的表达以及血脂水平的变化。
在第12周和第24周时，治疗组的ADAS-Cog、CIBIC-Plus和MMSE评分显著低于对照组（P<0.05）。对照组在第24周时所有临床量表评分与治疗前相比均有显著差异（P<0.05）。两组中IL-6、IL-8和TNF-的表达随认知障碍临床量表的变化而显著降低。
银杏酮酯片可能通过调节VCIND相关促炎因子的表达来延缓VCIND患者认知障碍的发展。
