Kang Joo-Eun, Song In-Kyung, Lee Ji-Hyun, Hur Min, Kim Jin-Tae, Kim Hee-Soo
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.
J Clin Monit Comput. 2015 Aug;29(4):533-7. doi: 10.1007/s10877-015-9680-0. Epub 2015 Mar 8.
Pulse transit time (PTT) is the time that it takes for the arterial pulse pressure wave to travel from the aortic valve to the periphery. It is a simple noninvasive technique for evaluating vascular changes. This study investigated the vascular changes by propofol during the induction of anesthesia in pediatric patients with the measuring of PTT. Without premedication, 2 mg/kg of propofol was administered intravenously with monitoring of electrocardiogram (ECG) and photoplethysmograph (PPG) in 20 pediatric patients aged 3-7 years. The ECG and PPG data were obtained for 1 min before propofol injection (baseline PTT) and 2 min after administration of propofol in the operating room. The PTT was defined as the time interval from the R-wave on the ECG to the maximum upslope of the corresponding PPG. The PTT was calculated off-line after collecting the data. The mean baseline PTT was 166.2 ± 25.9 ms and maximum PTT after propofol injection was 315.9 ± 64.9 ms (the interval between injection and the peak was 17.3 ± 7.6 s). The PTT after the peak changed variously; most of the patients showed no plateau; the PTT decreased progressively after the peak. The PTT after propofol administration prolonged in short time and rapidly recovered toward to the baseline values in pediatric patients. In conclusion, the baseline PTT in children is shorter comparing with adults and the vasodilatory effect of propofol on the vessels as described by the PTT was rapid and the recovery was faster, although the response to propofol was more varied than in adults.
脉搏传输时间（PTT）是动脉脉搏压力波从主动脉瓣传输至外周所需的时间。它是一种用于评估血管变化的简单非侵入性技术。本研究通过测量PTT来调查小儿患者麻醉诱导期间丙泊酚引起的血管变化。20名3至7岁的小儿患者未使用术前药，静脉注射2mg/kg丙泊酚，并监测心电图（ECG）和光电容积脉搏波描记图（PPG）。在手术室中，于丙泊酚注射前1分钟（基线PTT）和注射后2分钟获取ECG和PPG数据。PTT定义为从ECG上的R波至相应PPG最大上升斜率的时间间隔。数据收集后离线计算PTT。平均基线PTT为166.2±25.9毫秒，丙泊酚注射后的最大PTT为315.9±64.9毫秒（注射至峰值的间隔为17.3±7.6秒）。峰值后的PTT变化各异；大多数患者未出现平台期；峰值后PTT逐渐下降。小儿患者丙泊酚给药后PTT在短时间内延长，并迅速恢复至基线值。总之，与成人相比，儿童的基线PTT较短，丙泊酚对血管的舒张作用如PTT所示迅速且恢复更快，尽管对丙泊酚的反应比成人更为多样。
