Lan Yuan-Chun, Shen Ching-Hui, Kang Hsung-Ming, Chong Fok-Ching
Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106, Taiwan, Republic of China.
Comput Methods Biomech Biomed Engin. 2012;15(9):949-52. doi: 10.1080/10255842.2011.567981. Epub 2011 May 24.
Pulse transit time (PTT) is the duration in which a pulse wave travels between two arterial sites within the same cardiac cycle. The aim of our study is to use PTT to examine propofol's effects on the vascular system. Methods. We collected data from 50 healthy women, between 28 and 51 years old, who underwent gynaecological surgery under general anaesthesia. The general anaesthesia was induced with propofol injection (2 mg/kg). PTT measurements were obtained from the R-wave of electrocardiogram and the pulse wave of photoplethysmograph. Two PTT values were obtained; one before (the control) and the other after propofol injection. The results were analysed by Student's t-test. Results. After propofol injection, the PTT was prolonged. The change in the PTT value from that of baseline was significant statistically (P < 0.05, by Student's t-test). The PTT change over time correlated with the degree of vasodilatation over time. Monitoring of PTT not only revealed the magnitude of vascular changes but also demonstrated the onset of vascular dilation, its peak and duration. We conclude that PTT is a useful guide in monitoring the drug kinetics of propofol.
脉搏传输时间（PTT）是指在同一个心动周期内脉搏波在两个动脉部位之间传播的持续时间。我们研究的目的是利用PTT来检测丙泊酚对血管系统的影响。方法。我们收集了50名年龄在28至51岁之间、在全身麻醉下接受妇科手术的健康女性的数据。全身麻醉通过丙泊酚注射（2毫克/千克）诱导。PTT测量值取自心电图的R波和光电容积脉搏波。获得了两个PTT值；一个是在丙泊酚注射前（对照），另一个是在丙泊酚注射后。结果通过学生t检验进行分析。结果。丙泊酚注射后，PTT延长。PTT值相对于基线值的变化具有统计学意义（通过学生t检验，P<0.05）。PTT随时间的变化与血管扩张程度随时间的变化相关。对PTT的监测不仅揭示了血管变化的幅度，还显示了血管扩张的起始、峰值和持续时间。我们得出结论，PTT是监测丙泊酚药物动力学的有用指标。
