都柏林念珠菌经血行播散致一名HIV-1与HCV合并感染患者发生脊椎椎间盘炎和脊柱脓肿
Hematogenous dissemination of Candida dubliniensis causing spondylodiscitis and spinal abscess in a HIV-1 and HCV-coinfected patient.
作者信息
Salzer Helmut J F, Rolling Thierry, Klupp Eva-Maria, Schmiedel Stefan
机构信息
Department of Internal Medicine I, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
出版信息
Med Mycol Case Rep. 2015 Feb 24;8:17-20. doi: 10.1016/j.mmcr.2015.02.001. eCollection 2015 Jun.
We report a case of spondylodiscitis and spinal abscess following haematogenous dissemination of the emerging yeast Candida dubliniensis in a human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV)-coinfected patient. Although C. dubliniensis is considered less virulent compared to its closest known relative Candida albicans, reports of severe fungal infections are increasing. This case indicates that the pathogenicity of C. dubliniensis may be higher than previously believed. Therefore fungal infections caused by this dimorph fungus should be kept in mind in immunocompromised patients with spondylodiscitis and spinal abscess.
我们报告了一例在人类免疫缺陷病毒1型（HIV-1）和丙型肝炎病毒（HCV）合并感染患者中，新型酵母菌都柏林念珠菌经血行播散后发生脊椎椎间盘炎和脊柱脓肿的病例。尽管与已知关系最近的白色念珠菌相比，都柏林念珠菌的毒力被认为较低，但严重真菌感染的报告却在增加。该病例表明，都柏林念珠菌的致病性可能高于先前认为的水平。因此，对于患有脊椎椎间盘炎和脊柱脓肿的免疫功能低下患者，应考虑到由这种双态真菌引起的真菌感染。
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