医院获得性革兰氏阴性血流分离株：体外抗生素效力比较

Nosocomial gram-negative bloodstream isolates: a comparison of in vitro antibiotic potency.

作者信息

Stanley G L, Pfaller M A, Mori M, Wenzel R P

机构信息

Department of Internal Medicine, University of Iowa College of Medicine, Iowa City.

出版信息

J Hosp Infect. 1989 Oct;14(3):217-25. doi: 10.1016/0195-6701(89)90038-8.

DOI:10.1016/0195-6701(89)90038-8

PMID:2575103

Abstract

Nosocomial bloodstream infections add to the morbidity, mortality and length of hospitalization that is attributed to the underlying diseases alone. We have compared the in vitro potency of fifteen antibiotics against 136 isolates from clinically significant nosocomial gram-negative bacteraemias. Ciprofloxacin was the most potent antibiotic and had the broadest spectrum of activity (98% of isolates susceptible, MIC90 range: 0.06-0.5 micrograms ml-1). We subjected all isolates to beta-lactamase induction but antibiotic susceptibility was unaffected by this procedure.

摘要

医院获得性血流感染增加了仅归因于基础疾病的发病率、死亡率和住院时间。我们比较了15种抗生素对136株临床显著的医院获得性革兰氏阴性菌血症分离株的体外抗菌效力。环丙沙星是最有效的抗生素，且具有最广的活性谱（98%的分离株敏感，MIC90范围：0.06 - 0.5微克/毫升）。我们对所有分离株进行了β-内酰胺酶诱导，但该操作未影响抗生素敏感性。