Kannan Meena A, Challa Sundaram, Kandadai Rukmini M, Uppin Megha S, Jabeen Sheik A, Borgohain Rupam
Department of Neurology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India.
Neurol India. 2015 Jan-Feb;63(1):30-4. doi: 10.4103/0028-3886.152629.
Paraneoplastic vasculitic neuropathy (PVN) is a rare paraneoplastic syndrome. It is characterized by non-systemic subacute vasculitic neuropathy. It is most commonly associated with small cell lung cancers (SCLC) and lymphomas. PVN presents as a painful symmetrical or asymmetrical sensorimotor axonal neuropathy. The neurological symptoms may predate the tumor and may be the initial manifestations, or they may develop after a tumor is diagnosed. Recognition of this entity is important because of its potential treatability.
To study the clinical features of PVN and briefly review the literature.
The data was collected retrospectively from the medical records of our hospital.
Of the 14 cases of paraneoplastic neuropathies, 4 had a PVN. The age of onset was more than 50 years and there was no sex preponderance. Pain was seen in three patients. Two patients were previously treated for a thymoma. Two patients, following their presentation with PVN, were diagnosed with a colonic carcinoma and lung carcinoma, respectively.
The recognition of PVN is important as this syndrome may respond to immunosuppression and tumor removal.
副肿瘤性血管炎性神经病变（PVN）是一种罕见的副肿瘤综合征。其特征为非系统性亚急性血管炎性神经病变。它最常与小细胞肺癌（SCLC）和淋巴瘤相关。PVN表现为疼痛性对称或不对称感觉运动性轴索性神经病变。神经症状可能先于肿瘤出现且可能是初始表现，也可能在肿瘤诊断后出现。认识到这种疾病很重要，因为它具有潜在的可治疗性。
研究PVN的临床特征并简要回顾文献。
数据从我院病历中回顾性收集。
在14例副肿瘤性神经病变患者中，4例患有PVN。发病年龄超过50岁，无性别差异。3例患者出现疼痛。2例患者曾接受胸腺瘤治疗。2例PVN患者分别被诊断为结肠癌和肺癌。
认识到PVN很重要，因为该综合征可能对免疫抑制和肿瘤切除有反应。
