Oh S J
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 39294, USA.
Neurol Clin. 1997 Nov;15(4):849-63. doi: 10.1016/s0733-8619(05)70351-0.
Paraneoplastic vasculitic neuropathy (PVN) is a rare paraneoplastic syndrome characterized by non-systemic subacute vasculitic neuropathy. The two cancers most commonly associated with PVN are small cell lung cancer (SCLC) and lymphomas. Neuropathy varies from mononeurotherapy multiplex to symmetrical polyneuropathy. Two helpful laboratory abnormalities are a high erythrocyte sedimentation rate (ESR) and high cerebro spinal fluid (CSF) protein content. Axonal neuropathy is the characteristic finding in electrophysiological studies. Nerve biopsy is crucial to document microvasculitis. Recognition of this entity is important because of its potential treatability. Unlike other paraneoplastic syndromes, anti-cancer chemotherapy and immunotherapy for vasculitis are both effective in this disorder.
副肿瘤性血管炎性神经病变（PVN）是一种罕见的副肿瘤综合征，其特征为非系统性亚急性血管炎性神经病变。与PVN最常相关的两种癌症是小细胞肺癌（SCLC）和淋巴瘤。神经病变范围从多灶性单神经病到对称性多发性神经病。两项有用的实验室异常指标是高红细胞沉降率（ESR）和高脑脊液（CSF）蛋白含量。轴索性神经病变是电生理研究中的特征性发现。神经活检对于证实微血管炎至关重要。认识到这一实体很重要，因为它具有潜在的可治疗性。与其他副肿瘤综合征不同，针对血管炎的抗癌化疗和免疫疗法在这种疾病中均有效。
