Deasy P B, Collins A E, MacCarthy D J, Russell R J
Department of Pharmaceutics, Trinity College, University of Dublin, Ireland.
J Pharm Pharmacol. 1989 Oct;41(10):694-9. doi: 10.1111/j.2042-7158.1989.tb06343.x.
Strips containing tetracycline hydrochloride or metronidazole 25% in polyhydroxybutyric acid as a biodegradable polymer matrix, showed sustained release in simulated gingival fluid pH 6.6 at 37 degrees C. When evaluated in patients suffering from advanced periodontal disease, the greatest response to therapy was observed with tetracycline hydrochloride strips inserted into periodontal pockets at four-day intervals for 16 days, compared with an untreated control group. A reduction in plaque index, gingival index and pocket depth was observed. A favourable alteration occurred in the microbial flora of treated pockets with an increase in the proportion of cocci and decrease in gram-negative rods, fusiforms and spirochetes. Metronidazole strips or root-planning tended not to be as effective. The clinical improvement produced by each treatment was not maintained when treatment was terminated.
含有盐酸四环素或甲硝唑（25%）并以聚羟基丁酸作为可生物降解聚合物基质的药条，在37℃、pH值为6.6的模拟龈沟液中显示出持续释放。在患有晚期牙周病的患者中进行评估时，与未治疗的对照组相比，每隔四天在牙周袋中插入盐酸四环素药条，持续16天，观察到对治疗的最大反应。观察到菌斑指数、牙龈指数和牙周袋深度降低。治疗的牙周袋微生物菌群发生了有利变化，球菌比例增加，革兰氏阴性杆菌、梭形菌和螺旋体减少。甲硝唑药条或根面平整往往效果不佳。治疗终止后，每种治疗产生的临床改善未得到维持。
