Mazhari Shahrzad, Tabrizi Yousef Moghadas, Nejad Alireza Ghaffari
From the Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran (SM, YMT); and the Department of Psychiatry, Kerman University of Medical Sciences, Kerman, Iran (AGN).
J Neuropsychiatry Clin Neurosci. 2015;27(2):127-32. doi: 10.1176/appi.neuropsych.13120392. Epub 2015 Mar 9.
Mental imagery impairment has been reported in schizophrenia. The present study aimed to investigate the neural evidence for mental imagery impairment in patients with schizophrenia. The study participants included 20 patients with chronic schizophrenia and 18 healthy control subjects. Event-related potentials were recorded during a mental hand rotation task, in which participants were instructed to judge the laterality of hands displayed in different orientations. The performances of patients were significantly less accurate and slower than control subjects on hand rotation task. Moreover, the patients showed significantly reduced rotation-related negativity amplitude for mental rotation effect. The results demonstrate mental imagery impairment in patients with schizophrenia at both the behavioral and neural levels.
精神分裂症患者存在心理意象障碍已见报道。本研究旨在探究精神分裂症患者心理意象障碍的神经学证据。研究参与者包括20名慢性精神分裂症患者和18名健康对照者。在一项心理手部旋转任务中记录事件相关电位，该任务要求参与者判断以不同方向呈现的手部的左右侧。在手部旋转任务中，患者的表现明显不如对照者准确，且速度更慢。此外，患者在心理旋转效应方面表现出旋转相关负波幅显著降低。结果表明，精神分裂症患者在行为和神经水平上均存在心理意象障碍。
