一种表观遗传调节因子：甲基化CpG结合结构域蛋白1（MBD1）。
An epigenetic regulator: methyl-CpG-binding domain protein 1 (MBD1).
作者信息
Li Lu, Chen Bi-Feng, Chan Wai-Yee
机构信息
The Chinese University of Hong Kong-Chinese Academy of Sciences Guangzhou Institute of Biomedicine and Health Joint Laboratory on Stem Cell and Regenerative Medicine, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
出版信息
Int J Mol Sci. 2015 Mar 5;16(3):5125-40. doi: 10.3390/ijms16035125.
DNA methylation is an important form of epigenetic regulation in both normal development and cancer. Methyl-CpG-binding domain protein 1 (MBD1) is highly related to DNA methylation. Its MBD domain recognizes and binds to methylated CpGs. This binding allows it to trigger methylation of H3K9 and results in transcriptional repression. The CXXC3 domain of MBD1 makes it a unique member of the MBD family due to its affinity to unmethylated DNA. MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex. As methylation status always changes along with carcinogenesis or neurogenesis, MBD1 with its interacting partners, including proteins and non-coding RNAs, participates in normal or pathological processes and functions in different regulatory systems. Because of the important role of MBD1 in epigenetic regulation, it is a good candidate as a therapeutic target for diseases.
DNA甲基化是正常发育和癌症中表观遗传调控的一种重要形式。甲基-CpG结合域蛋白1（MBD1）与DNA甲基化高度相关。其MBD结构域识别并结合甲基化的CpG。这种结合使其能够触发H3K9的甲基化并导致转录抑制。MBD1的CXXC3结构域由于其对未甲基化DNA的亲和力而使其成为MBD家族的独特成员。MBD1通过不同机制发挥表观遗传调节作用，例如形成MCAF1/MBD1/SETDB1复合物或MBD1-HDAC3复合物。由于甲基化状态总是随着致癌作用或神经发生而变化，MBD1及其相互作用伙伴，包括蛋白质和非编码RNA，参与正常或病理过程并在不同调节系统中发挥作用。由于MBD1在表观遗传调控中的重要作用，它是作为疾病治疗靶点的良好候选者。
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