Peng Tao, Zhou Xuhong, Hu Min, Wu Tingting
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Nov;28(22):1780-2.
To investigate the expression of miRNA-204 in patients with NPC and to analyze the as- sociation of the expression with the cIinicopathologicaI features and prognosis.
The expression levels of miRNA-204 in 50 patients with NPC and 40 patients with nasopharyngeal chronic inflammation were detected by using stem-loop real-time reverse transcription-polymerase chain reaction RT-PCR. Analysis of the relationship between microRNA and prognosis by Kaplan-Meier method.
Expression levels of miRNA-204 were down- regulated in patients with NPC as compared with patients with nasopharyngeal chronic inflammation (P < 0.05). The expression of miRNA-204 was associated with EBV infection, differentiation, lymphatic metastasis and TNM stages (P < 0.05). Low miRNA-204 expression was significantly correlated with shorter overall survival (P < 0.05) of NPC.
The downregulation of miRNA-204 expression has related with disease progression and miRNA-204 can serve as a potential therapeutic target for NPC.
探讨微小RNA-204（miRNA-204）在鼻咽癌（NPC）患者中的表达情况，并分析其表达与临床病理特征及预后的相关性。
采用茎环实时逆转录-聚合酶链反应（RT-PCR）检测50例NPC患者和40例鼻咽部慢性炎症患者中miRNA-204的表达水平。采用Kaplan-Meier法分析微小RNA与预后的关系。
与鼻咽部慢性炎症患者相比，NPC患者中miRNA-204的表达水平下调（P<0.05）。miRNA-204的表达与EB病毒感染、分化程度、淋巴结转移及TNM分期相关（P<0.05）。低miRNA-204表达与NPC患者较短的总生存期显著相关（P<0.05）。
miRNA-204表达下调与疾病进展有关，miRNA-204可作为NPC潜在的治疗靶点。
