Stanek Johann, Mairinger Severin, Wanek Thomas, Kuntner Claudia, Müller Markus, Langer Oliver
Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Währiger-Gürtel 18-20, A-1090 Vienna, Austria.
Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria.
Appl Radiat Isot. 2015 May;99:133-7. doi: 10.1016/j.apradiso.2015.02.024. Epub 2015 Feb 27.
We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing the standard 15-mL glassy carbon reactor of the synthesis module with a 3-mL V-shaped borosilicate glass reactor a considerable improvement in RCY was observed. [(18)F]Ciprofloxacin was obtained in a RCY of 2.7±1.4% (n=23) with a specific activity at EOS of 1.4±0.5GBq/µmol in a synthesis time of 160min.
我们将先前发表的[(18)F]环丙沙星的手动合成方法（衰变校正后的放射性化学产率：5.5±1.0%）转移至自动化合成模块（TRACERlab(TM) FXFDG，通用电气医疗集团），并观察到放射性化学产率大幅下降（0.4±0.4%）。当将合成模块的标准15 mL玻璃碳反应器替换为3 mL V形硼硅酸盐玻璃反应器时，观察到放射性化学产率有显著提高。[(18)F]环丙沙星的放射性化学产率为2.7±1.4%（n = 23），在合成160分钟后，终态比活度为1.4±0.5GBq/µmol。
