使用Tracerlab FXFN和Tracerlab MXFDG模块自动合成[18F]PBR111和[18F]PBR102，用于正电子发射断层扫描（PET）对外周苯二氮䓬受体进行成像。
Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the Tracerlab FXFN and Tracerlab MXFDG module for imaging the peripheral benzodiazepine receptor with PET.
作者信息
Bourdier Thomas, Pham Tien Q, Henderson David, Jackson Timothy, Lam Peter, Izard Michael, Katsifis Andrew
机构信息
PET and Nuclear Medicine Department, Royal Prince Alfred Hospital, Missenden road, Camperdown NSW 2050, Sydney, Australia.
出版信息
Appl Radiat Isot. 2012 Jan;70(1):176-83. doi: 10.1016/j.apradiso.2011.07.014. Epub 2011 Aug 5.
[(18)F]PBR111 and [(18)F]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [(18)F]PBR111 and [(18)F]PBR102 in the Tracerlab FX(FN) (30±2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MX(FDG) (25±2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was >99% and specific activity was >150GBq/μmol after less than 60min of preparation time.
[（18）F]PBR111和[（18）F]PBR102是用于外周苯二氮䓬受体（PBR）成像的选择性放射性配体。我们已经开发出一种全自动方法，可在Tracerlab FX(FN)（两种示踪剂的非衰变校正放射化学产率为30±2%）和Tracerlab MX(FDG)（两种示踪剂的非衰变校正放射化学产率为25±2%）中，由相应的对甲苯磺酰前体放射性合成[（18）F]PBR111和[（18）F]PBR102。对于所有示踪剂，制备时间少于60分钟后，放射化学纯度>99%，比活度>150GBq/μmol。
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