[18F]氟乙酸钠全自动合成的新方法——一种使用商用合成仪的简单快速方法。
New approach to fully automated synthesis of sodium [18F]fluoroacetate -- a simple and fast method using a commercial synthesizer.
作者信息
Sun Li-Quan, Mori Tetsuya, Dence Carmen S, Ponde Datta E, Welch Michael J, Furukawa Takako, Yonekura Yoshiharu, Fujibayashi Yasuhisa
机构信息
Biomedical Imaging Research Center, University of Fukui, Yoshida, Japan.
出版信息
Nucl Med Biol. 2006 Jan;33(1):153-8. doi: 10.1016/j.nucmedbio.2005.07.005.
A simple, rapid and fully automated preparation of sodium [(18)F]fluoroacetate has been developed by taking advantage of the similarities between the reaction pathways of [(18)F]fluoroacetate and [(18)F]-2-fluoro-deoxyglucose (FDG). The automated synthesis of sodium [(18)F]fluoroacetate was achieved with a commercial [(18)F]FDG synthesizer, the TRACERlab MX(FDG). The method produced the desired compound in a short synthesis time (32 min) and with a high and reproducible radiochemical yield (50.2 +/- 4.8%, decay corrected). The radiochemical purity of sodium [(18)F]fluoroacetate was greater than 99%.
利用[¹⁸F]氟乙酸盐和[¹⁸F]-2-氟-脱氧葡萄糖（FDG）反应途径的相似性，开发了一种简单、快速且完全自动化的[¹⁸F]氟乙酸钠制备方法。使用商用[¹⁸F]FDG合成仪TRACERlab MX(FDG)实现了[¹⁸F]氟乙酸钠的自动化合成。该方法在短合成时间（32分钟）内产生了所需化合物，并且具有高且可重复的放射化学产率（衰变校正后为50.2±4.8%）。[¹⁸F]氟乙酸钠的放射化学纯度大于99%。
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