Penn State College of Medicine, Hershey, Pennsylvania.
Department of Dermatology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
J Am Acad Dermatol. 2015 May;72(5):822-7. doi: 10.1016/j.jaad.2015.01.048. Epub 2015 Mar 7.
The duration of oral antibiotic acne therapy for adolescents compared with guidelines was recently investigated; however it was uncertain if duration of antibiotics for adult acne therapy differed.
This study aimed to evaluate duration of oral antibiotics for adult acne compared with guidelines and determine possible cost-savings.
This was a retrospective cohort study of MarketScan Commercial Claims and Encounters database that incorporated claims data to determine duration and costs of antibiotic treatment among adults ages 21 years and older.
Of 17,448 courses, 84.5% (14,737) aligned with duration guidelines, although 12,040 (69.0%) courses did not include concomitant topical retinoid therapy. Mean savings of $592.26 per person could result if prolonged courses met guidelines. Mean (median) costs of generic and branded formulations for the most frequent course duration (90-179 days) were $103.77 ($54.27) and $1421.61 ($1462.25), respectively.
Actual patient prescription adherence is uncertain and database lacks information regarding acne severity, patient physical characteristics, and clinical outcomes.
The majority of oral antibiotic course durations follow guidelines, although topical retinoids are underused. Costs of antibiotic therapy were lower for shorter courses and those using generic medications; the cost-effectiveness of these modifications has not been investigated.
最近研究了青少年口服抗生素痤疮治疗的持续时间与指南的比较；然而，成人痤疮治疗的抗生素持续时间是否不同仍不确定。
本研究旨在评估成人痤疮口服抗生素的持续时间与指南的比较，并确定可能的成本节约。
这是一项回顾性队列研究，使用 MarketScan 商业索赔和就诊数据库，纳入了索赔数据，以确定 21 岁及以上成年人抗生素治疗的持续时间和费用。
在 17448 个疗程中，84.5%（14737 个）符合持续时间指南，尽管 12040 个（69.0%）疗程未包括同时使用局部维甲酸治疗。如果延长疗程符合指南，每人可节省 592.26 美元。最常见疗程（90-179 天）的通用和品牌制剂的平均（中位数）费用分别为 103.77 美元（54.27 美元）和 1421.61 美元（1462.25 美元）。
实际患者处方依从性不确定，数据库缺乏关于痤疮严重程度、患者身体特征和临床结果的信息。
大多数口服抗生素疗程持续时间符合指南，尽管局部维甲酸的使用不足。较短疗程和使用通用药物的抗生素治疗费用较低；这些修改的成本效益尚未得到调查。
