Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, 4339 CNSI, 570 Westwood Plaza, Building 114, Los Angeles, CA, 90095, USA.
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China.
Am J Clin Dermatol. 2019 Jun;20(3):335-344. doi: 10.1007/s40257-018-00417-3.
Acne vulgaris is a chronic skin disorder involving hair follicles and sebaceous glands. Multiple factors contribute to the disease, including skin microbes. The skin microbiome in the follicle is composed of a diverse group of microorganisms. Among them, Propionibacterium acnes and Malassezia spp. have been linked to acne development through their influence on sebum secretion, comedone formation, and inflammatory response. Antibiotics targeting P. acnes have been the mainstay in acne treatment for the past four decades. Among them, macrolides, clindamycin, and tetracyclines are the most widely prescribed. As antibiotic resistance becomes an increasing concern in clinical practice, understanding the skin microbiome associated with acne and the effects of antibiotic use on the skin commensals is highly relevant and critical to clinicians. In this review, we summarize recent studies of the composition and dynamics of the skin microbiome in acne and the effects of antibiotic treatment on skin microbes.
寻常痤疮是一种累及毛囊和皮脂腺的慢性皮肤疾病。多种因素可诱发该病，包括皮肤微生物。毛囊中的皮肤微生物组由多种微生物组成。其中，痤疮丙酸杆菌和马拉色菌通过影响皮脂分泌、粉刺形成和炎症反应与痤疮的发生发展有关。过去四十年，针对痤疮丙酸杆菌的抗生素一直是痤疮治疗的主要手段。其中，大环内酯类、克林霉素和四环素类应用最为广泛。随着抗生素耐药性在临床实践中日益受到关注，了解与痤疮相关的皮肤微生物组以及抗生素使用对皮肤共生菌的影响，对于临床医生来说非常重要。本综述总结了近年来有关痤疮皮肤微生物组的组成和动态变化以及抗生素治疗对皮肤微生物影响的研究进展。
