Division of Paediatric Nephrology, Children's Hospital Los Angeles, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA.
Division of Paediatric Nephrology, Rady Children's Hospital, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0630, USA.
Nat Rev Nephrol. 2015 May;11(5):257-8. doi: 10.1038/nrneph.2015.26. Epub 2015 Mar 10.
A new trial provides further evidence that rituximab treatment can reduce the risk of relapse in children with steroid-dependent idiopathic nephrotic syndrome. Addition of a single infusion of rituximab to steroid therapy was associated with a decrease in proteinuria at 3 months and a significant increase in the relapse-free period.
一项新的试验提供了进一步的证据，表明利妥昔单抗治疗可以降低类固醇依赖型特发性肾病综合征儿童的复发风险。在类固醇治疗的基础上加用单次利妥昔单抗输注可使 3 个月时蛋白尿减少，并显著延长无复发期。
