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高血压:DENERHTN 试验带来的令人振奋的肾脏去神经术数据。

Hypertension: Renal denervation-promising data from the DENERHTN trial.

机构信息

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Kapucijnenvoer 35, Box 7001, BE-3000 Leuven, Belgium.

出版信息

Nat Rev Nephrol. 2015 May;11(5):258-60. doi: 10.1038/nrneph.2015.28. Epub 2015 Mar 10.

DOI:10.1038/nrneph.2015.28
PMID:25752835
Abstract

In patients with resistant hypertension, renal denervation plus standardized stepped-care antihypertensive treatment (SSAHT) resulted in significant blood-pressure lowering compared with SSAHT alone. These new data from the DENERHTN trial may indicate that despite the failure of SYMPLICITY HTN-3, there is light at the end of the tunnel for renal denervation.

摘要

在耐药性高血压患者中,与单独接受标准化阶梯式降压治疗(SSAHT)相比,肾去神经术加 SSAHT 可显著降低血压。来自 DENERHTN 试验的这些新数据可能表明,尽管 SYMPLICITY HTN-3 试验失败,但肾去神经术仍有一线希望。

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2
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本文引用的文献

1
Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial.优化和分级照护标准化抗高血压治疗联合或不联合肾去神经术治疗耐药性高血压(DENERHTN):一项多中心、开放标签、随机对照试验。
Lancet. 2015 May 16;385(9981):1957-65. doi: 10.1016/S0140-6736(14)61942-5. Epub 2015 Jan 26.
2
Randomized comparison of renal denervation versus intensified pharmacotherapy including spironolactone in true-resistant hypertension: six-month results from the Prague-15 study.随机比较肾去神经术与强化药物治疗(包括螺内酯)在真性耐药高血压中的效果:来自布拉格-15 研究的 6 个月结果。
Hypertension. 2015 Feb;65(2):407-13. doi: 10.1161/HYPERTENSIONAHA.114.04019. Epub 2014 Nov 24.
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Blood pressure response to renal nerve stimulation in patients undergoing renal denervation: a feasibility study.肾去神经支配患者对肾神经刺激的血压反应:一项可行性研究。
J Hum Hypertens. 2015 May;29(5):292-5. doi: 10.1038/jhh.2014.91. Epub 2014 Oct 23.
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A controlled trial of renal denervation for resistant hypertension.经导管射频消融去肾交感神经术治疗高血压的对照试验
N Engl J Med. 2014 Apr 10;370(15):1393-401. doi: 10.1056/NEJMoa1402670. Epub 2014 Mar 29.
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Adjusted drug treatment is superior to renal sympathetic denervation in patients with true treatment-resistant hypertension.对于真正难治性高血压患者,调整药物治疗优于肾交感神经去神经支配术。
Hypertension. 2014 May;63(5):991-9. doi: 10.1161/HYPERTENSIONAHA.114.03246. Epub 2014 Mar 3.
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JAMA. 2012 Feb 8;307(6):567-8. doi: 10.1001/jama.2012.115.
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Catheter-based renal sympathetic denervation for resistant hypertension: durability of blood pressure reduction out to 24 months.经导管去肾交感神经术治疗耐药性高血压:降压效果可持续 24 个月。
Hypertension. 2011 May;57(5):911-7. doi: 10.1161/HYPERTENSIONAHA.110.163014. Epub 2011 Mar 14.
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Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial.治疗抵抗性高血压患者的肾脏去神经支配(Symplicity HTN-2 试验):一项随机对照试验。
Lancet. 2010 Dec 4;376(9756):1903-9. doi: 10.1016/S0140-6736(10)62039-9. Epub 2010 Nov 17.
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Antihypertensive treatment based on blood pressure measurement at home or in the physician's office: a randomized controlled trial.基于家庭或医生办公室血压测量的降压治疗:一项随机对照试验。
JAMA. 2004 Feb 25;291(8):955-64. doi: 10.1001/jama.291.8.955.
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Increased peripheral release of noradrenaline and uptake of adrenaline in essential hypertension?
Clin Sci (Lond). 1981 Dec;61 Suppl 7:215s-217s. doi: 10.1042/cs061215s.