Kaden J, Falck P, Eichler C, Strobelt V, May G, Volk H D
Abteilung für Experimentelle Organtransplantation der Urologischen Klinik des Bereiches Medizin Humboldt-Universität zu Berlin.
Z Urol Nephrol. 1989 Oct;82(10):531-9.
In 10 patients after kidney transplantation the T cell subpopulations (CD4, CD8) and the number of activated lymphocytes (IL-2R and transferrin receptor+, 4F2+, HLA-DR+, CD3+) in the peripheral blood were determined. In 9 out of 9 cases with rejection a clear immune activation could observed. In patients with CMV-associated rejection crisis the CD4/CD8 ratio was significantly higher compared with patients with rejection crisis but without CMV infection. In all patients with CMV infection (n = 5) an increase of activated lymphocytes was observed. In a clinical-immunological monitoring the dynamics of the CD4/CD8 ratio, the expression of activation marker (especially CD3+, HLA-DR+ and 4F2+) and the absolute number of lymphocyte subpopulations should included.
对10例肾移植患者外周血中的T细胞亚群（CD4、CD8）以及活化淋巴细胞（IL-2R和转铁蛋白受体阳性、4F2阳性、HLA-DR阳性、CD3阳性）数量进行了测定。在9例发生排斥反应的患者中，均观察到明显的免疫激活。与发生排斥反应但无巨细胞病毒（CMV）感染的患者相比，发生CMV相关排斥反应危象的患者CD4/CD8比值显著更高。在所有CMV感染患者（n = 5）中，均观察到活化淋巴细胞增加。在临床免疫监测中，应纳入CD4/CD8比值的动态变化、活化标志物（尤其是CD3阳性、HLA-DR阳性和4F2阳性）的表达以及淋巴细胞亚群的绝对数量。
