Karg E, Rosengren E, Rorsman H
Department of Dermatology, University of Lund, Sweden.
Acta Derm Venereol. 1989;69(6):521-4.
Isoprenaline (0.3 mM) moderately increased the tyrosinase activity of cultured human melanoma cells, while another beta-adrenoceptor agonist, terbutaline (1-3 mM) and a catechol compound, dopac (0.1-0.3 mM) induced a several fold increase in the enzyme activity. Isoprenaline (0.3-1 mM) and dopac (0.3-1 mM) also exerted pronounced toxic effects on the cells. The data suggest: 1) a possible role for beta-adrenoceptors in the regulation of human melanogenesis; 2) two different ways of action for isoprenaline in inducing tyrosinase elevation; 3) the possible usefulness of dopac as a chemotherapeutic agent.
异丙肾上腺素（0.3 mM）适度增加了培养的人黑色素瘤细胞的酪氨酸酶活性，而另一种β-肾上腺素能受体激动剂特布他林（1 - 3 mM）和一种儿茶酚化合物多巴（0.1 - 0.3 mM）使该酶活性增加了几倍。异丙肾上腺素（0.3 - 1 mM）和多巴（0.3 - 1 mM）对细胞也有明显的毒性作用。这些数据表明：1）β-肾上腺素能受体在人类黑素生成调节中可能发挥作用；2）异丙肾上腺素诱导酪氨酸酶升高有两种不同的作用方式；3）多巴作为一种化疗药物可能具有的效用。
