通过钯催化的烯烃与不稳定烯丙基对甲苯磺酰腙的分子内环丙烷化反应制备乙烯基环丙烷。
An entry to vinylcyclopropane through palladium-catalyzed intramolecular cyclopropanation of alkenes with unstabilized allylic tosylhydrazones.
作者信息
Yang Yang, Li Jinpeng, Du Biao, Yuan Changchun, Liu Bo, Qin Song
机构信息
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
出版信息
Chem Commun (Camb). 2015 Apr 11;51(28):6179-82. doi: 10.1039/c5cc00235d.
PMID:25753475
Abstract
A diastereoselective Pd-catalyzed intramolecular cyclopropanation of alkenes with unstabilized allylic tosylhydrazones was developed. This methodology provides an efficient entry toward synthesis of the bicyclo[3.1.0] hexane system with an exo-double bond, and sets the basis for future elaboration of more complex polycyclic motifs.
摘要
开发了一种非对映选择性钯催化的烯烃与不稳定烯丙基对甲苯磺酰腙的分子内环丙烷化反应。该方法为合成具有外环双键的双环[3.1.0]己烷体系提供了一条有效途径，并为未来构建更复杂的多环结构奠定了基础。
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