Delahunt Brett, Srigley John R
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago Wellington, PO Box 7343, Wellington, New Zealand.
Department of Pathology and Molecular Medicine, McMaster University, Toronto, Canada.
Semin Diagn Pathol. 2015 Mar;32(2):90-102. doi: 10.1053/j.semdp.2015.02.002. Epub 2015 Feb 4.
The classification of renal cell neoplasia is morphologically based; however, this has evolved over the last 35 years with the incorporation of genetic characteristics into the diagnostic features of some tumors. The 2013 Vancouver classification recognized 17 morphotypes of renal parenchymal malignancy and two benign tumors. This classification included the newly established entities tubulocystic renal cell carcinoma (RCC)), acquired cystic disease-associated RCC, clear cell (tubulo) papillary RCC, microphthalmia transcription factor family translocation RCC and hereditary leiomyomatosis RCC syndrome-associated RCC. In addition to these newly described forms of RCC there are a number of novel tumors that are currently recognized as emerging entities. These are likely to be incorporated into subsequent classifications and include thyroid-like follicular RCC, succinate dehydrogenase B mutation-associated RCC, ALK translocation RCC, tuberous sclerosis complex-associated RCC, and RCC with (angio) leiomyomatous stroma.
肾细胞肿瘤的分类基于形态学；然而，在过去35年里，随着一些肿瘤的诊断特征纳入了基因特征，这种分类方法也有所发展。2013年温哥华分类法确认了17种肾实质恶性肿瘤的形态类型和两种良性肿瘤。该分类包括新确立的实体：肾小管囊性肾细胞癌（RCC）、获得性囊性疾病相关性RCC、透明细胞（小管）乳头状RCC、小眼转录因子家族易位性RCC以及遗传性平滑肌瘤病RCC综合征相关性RCC。除了这些新描述的RCC形式之外，还有一些目前被认为是新兴实体的新型肿瘤。它们很可能会被纳入后续分类中，包括甲状腺样滤泡性RCC、琥珀酸脱氢酶B突变相关性RCC、ALK易位性RCC、结节性硬化症复合物相关性RCC以及伴有（血管）平滑肌瘤样间质的RCC。
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