对头孢托罗培南和头孢洛林耐药的耐甲氧西林金黄色葡萄球菌
Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus.
作者信息
Chan Liana C, Basuino Li, Diep Binh, Hamilton Stephanie, Chatterjee Som S, Chambers Henry F
机构信息
Division of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA Division of Molecular Medicine, Harbor-UCLA Medical Center, Torrance, California, USA
Division of Infectious Disease, Department of Medicine, San Francisco General Hospital, San Francisco, California, USA.
出版信息
Antimicrob Agents Chemother. 2015 May;59(5):2960-3. doi: 10.1128/AAC.05004-14. Epub 2015 Mar 9.
Abstract
The role of mecA mutations in conferring resistance to ceftobiprole and ceftaroline, cephalosporins with anti-methicillin-resistant Staphylococcus aureus (MRSA) activity, was determined with MRSA strains COL and SF8300. The SF8300 ceftaroline-passaged mutant carried a single mecA mutation, E447K (E-to-K change at position 447), and expressed low-level resistance. This mutation in COL conferred high-level resistance to ceftobiprole but only low-level resistance to ceftaroline. The COL ceftaroline-passaged mutant, which expressed high-level resistance to ceftobiprole and ceftaroline, had mutations in pbp2, pbp4, and gdpP but not mecA.
摘要
利用耐甲氧西林金黄色葡萄球菌（MRSA）菌株COL和SF8300，确定了mecA突变在赋予对头孢比普和头孢洛林（具有抗MRSA活性的头孢菌素）耐药性方面的作用。经头孢洛林传代的SF8300突变体携带单个mecA突变，即E447K（第447位发生E到K的变化），并表现出低水平耐药性。COL中的这种突变赋予对头孢比普的高水平耐药性，但仅对头孢洛林表现出低水平耐药性。对头孢比普和头孢洛林均表现出高水平耐药性的COL头孢洛林传代突变体在pbp2、pbp4和gdpP中存在突变，但mecA未发生突变。
相似文献
1
Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus.对头孢托罗培南和头孢洛林耐药的耐甲氧西林金黄色葡萄球菌
Antimicrob Agents Chemother. 2015 May;59(5):2960-3. doi: 10.1128/AAC.05004-14. Epub 2015 Mar 9.
2
Characterization of an osteomyelitis case caused by dalbavancin, ceftaroline, and vancomycin non-susceptible methicillin-resistant Staphylococcus aureus.耐甲氧西林金黄色葡萄球菌所致骨髓炎病例的特征：达巴万星、头孢洛林和万古霉素不敏感。
Eur J Clin Microbiol Infect Dis. 2021 Sep;40(9):2029-2032. doi: 10.1007/s10096-021-04219-0. Epub 2021 Mar 8.
3
Ceftaroline Resistance Selection of Methicillin-Resistant Involves Different Genetic Pathways.头孢洛林耐药性选择与耐甲氧西林有关，涉及不同的遗传途径。
Microb Drug Resist. 2019 Dec;25(10):1401-1409. doi: 10.1089/mdr.2019.0130. Epub 2019 Jul 19.
4
Genotypic analysis of Italian MRSA strains exhibiting low-level ceftaroline and ceftobiprole resistance.意大利耐低浓度头孢洛林和头孢比普酯的耐甲氧西林金黄色葡萄球菌（MRSA）菌株的基因分析。
Diagn Microbiol Infect Dis. 2019 Nov;95(3):114852. doi: 10.1016/j.diagmicrobio.2019.06.004. Epub 2019 Jun 15.
5
In vitro activity of ceftaroline and ceftobiprole against methicillin-resistant Staphylococcus aureus with decreased susceptibility to vancomycin isolated in paediatric patients.头孢洛林和头孢比普对儿科患者中分离出的对万古霉素敏感性降低的耐甲氧西林金黄色葡萄球菌的体外活性。
J Chemother. 2018 Oct-Dec;30(6-8):338-341. doi: 10.1080/1120009X.2018.1522473. Epub 2018 Oct 30.
6
Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance.耐第五代头孢菌素的耐甲氧西林金黄色葡萄球菌全基因组测序揭示了潜在的非mecA耐药机制。
PLoS One. 2016 Feb 18;11(2):e0149541. doi: 10.1371/journal.pone.0149541. eCollection 2016.
7
Missense mutations of PBP2a are associated with reduced susceptibility to ceftaroline and ceftobiprole in African MRSA.PBP2a的错义突变与非洲耐甲氧西林金黄色葡萄球菌（MRSA）对头孢洛林和头孢比普的敏感性降低有关。
J Antimicrob Chemother. 2016 Jan;71(1):41-4. doi: 10.1093/jac/dkv325. Epub 2015 Oct 5.
8
High Rate of Ceftobiprole Resistance among Clinical Methicillin-Resistant Isolates from a Hospital in Central Italy.意大利中部某医院耐甲氧西林金黄色葡萄球菌临床分离株中头孢妥仑耐药率较高。
Antimicrob Agents Chemother. 2018 Nov 26;62(12). doi: 10.1128/AAC.01663-18. Print 2018 Dec.
9
Reduced In Vitro Activity of Ceftaroline by Etest among Clonal Complex 239 Methicillin-Resistant Staphylococcus aureus Clinical Strains from Australia.在来自澳大利亚的克隆复合体239耐甲氧西林金黄色葡萄球菌临床菌株中，Etest法检测显示头孢洛林的体外活性降低
Antimicrob Agents Chemother. 2015 Dec;59(12):7837-41. doi: 10.1128/AAC.02015-15. Epub 2015 Sep 21.
10
Antimicrobial activity of ceftaroline against methicillin-resistant Staphylococcus aureus (MRSA) isolates collected in 2013-2014 at the Geneva University Hospitals.2013 - 2014年在日内瓦大学医院收集的耐甲氧西林金黄色葡萄球菌（MRSA）分离株对头孢洛林的抗菌活性。
Eur J Clin Microbiol Infect Dis. 2017 Feb;36(2):343-350. doi: 10.1007/s10096-016-2807-5. Epub 2016 Oct 15.
引用本文的文献
1
Comparative Effects of Intermittent vs. Constant Ceftiofur Hydrochloride Exposure on In Vitro.间歇性与持续性暴露于盐酸头孢噻呋对体外的比较影响
Antibiotics (Basel). 2025 Jul 6;14(7):686. doi: 10.3390/antibiotics14070686.
2
Cyclic-di-AMP modulates cellular turgor in response to defects in bacterial cell wall synthesis.环二腺苷酸响应细菌细胞壁合成缺陷调节细胞膨压。
Nat Microbiol. 2025 Jun 17. doi: 10.1038/s41564-025-02027-2.
3
Evidence of -mediated β-lactam antibiotic resistance transfer to from sp. nov., a psychrophilic bacterium from food-producing animals and human clinical specimens.介导的β-内酰胺抗生素耐药性从新种（一种来自产食动物和人类临床标本的嗜冷细菌）转移至的证据。
Appl Environ Microbiol. 2025 Apr 23;91(4):e0165224. doi: 10.1128/aem.01652-24. Epub 2025 Mar 11.
4
ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics.ESKAPE 病原体：抗微生物药物耐药性、流行病学、临床影响和治疗学。
Nat Rev Microbiol. 2024 Oct;22(10):598-616. doi: 10.1038/s41579-024-01054-w. Epub 2024 Jun 3.
5
Reducing Peptidoglycan Crosslinking by Chemical Modulator Reverts β-lactam Resistance in Methicillin-Resistant Staphylococcus aureus.化学调节剂降低肽聚糖交联可恢复耐甲氧西林金黄色葡萄球菌的β-内酰胺类药物耐药性。
Adv Sci (Weinh). 2024 Jul;11(28):e2400858. doi: 10.1002/advs.202400858. Epub 2024 May 15.
6
Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in .改变的 PBP4 和 GdpP 功能协同介导. 类似 MRSA 的高水平、广谱β-内酰胺耐药性。
mBio. 2024 May 8;15(5):e0288923. doi: 10.1128/mbio.02889-23. Epub 2024 Mar 26.
7
Molecular Determinants of β-Lactam Resistance in Methicillin-Resistant (MRSA): An Updated Review.耐甲氧西林金黄色葡萄球菌（MRSA）中β-内酰胺耐药性的分子决定因素：最新综述
Antibiotics (Basel). 2023 Aug 24;12(9):1362. doi: 10.3390/antibiotics12091362.
8
Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus.金黄色葡萄球菌广谱β-内酰胺类抗生素耐药的结构基础。
Nature. 2023 Jan;613(7943):375-382. doi: 10.1038/s41586-022-05583-3. Epub 2023 Jan 4.
9
Synergistic Combinations of FDA-Approved Drugs with Ceftobiprole against Methicillin-Resistant Staphylococcus aureus.与头孢托罗匹酯协同作用的 FDA 批准药物对耐甲氧西林金黄色葡萄球菌的联合治疗。
Microbiol Spectr. 2023 Feb 14;11(1):e0372622. doi: 10.1128/spectrum.03726-22. Epub 2022 Dec 15.
10
Inhibition of the Quorum Sensing System, Elastase Production and Biofilm Formation in by Psammaplin A and Bisaprasin.Psammaplin A 和 Bisaprasin 抑制 中的群体感应系统、弹性蛋白酶产生和生物膜形成。
Molecules. 2022 Mar 6;27(5):1721. doi: 10.3390/molecules27051721.
本文引用的文献
1
PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates.导致临床耐甲氧西林金黄色葡萄球菌分离株对头孢洛林高水平耐药的PBP2a突变
Antimicrob Agents Chemother. 2014 Nov;58(11):6668-74. doi: 10.1128/AAC.03622-14. Epub 2014 Aug 25.
2
Analysis of Staphylococcus aureus clinical isolates with reduced susceptibility to ceftaroline: an epidemiological and structural perspective.对头孢洛林敏感性降低的金黄色葡萄球菌临床分离株的分析：流行病学和结构视角
J Antimicrob Chemother. 2014 Aug;69(8):2065-75. doi: 10.1093/jac/dku114. Epub 2014 Apr 28.
3
How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function.别构调控金黄色葡萄球菌青霉素结合蛋白 2a 实现耐甲氧西林和生理功能。
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16808-13. doi: 10.1073/pnas.1300118110. Epub 2013 Oct 1.
4
Ceftaroline fosamil: a new cephalosporin active against resistant Gram-positive organisms including MRSA.头孢替坦二聚体：一种新型头孢菌素，对包括耐甲氧西林金黄色葡萄球菌（MRSA）在内的耐药革兰阳性菌具有活性。
Expert Rev Anti Infect Ther. 2012 Oct;10(10):1087-103. doi: 10.1586/eri.12.112. Epub 2012 Nov 21.
5
Structural insights into the anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of ceftobiprole.头孢托罗的抗耐甲氧西林金黄色葡萄球菌（MRSA）活性的结构见解。
J Biol Chem. 2012 Sep 14;287(38):32096-102. doi: 10.1074/jbc.M112.355644. Epub 2012 Jul 19.
6
Improving known classes of antibiotics: an optimistic approach for the future.提高已知类型抗生素的疗效：面向未来的乐观策略。
Curr Opin Pharmacol. 2012 Oct;12(5):527-34. doi: 10.1016/j.coph.2012.06.003. Epub 2012 Jun 28.
7
Characterization of methicillin-resistant Staphylococcus aureus displaying increased MICs of ceftaroline.耐甲氧西林金黄色葡萄球菌中 ceftaroline MIC 值升高的特性研究
J Antimicrob Chemother. 2012 Jun;67(6):1321-4. doi: 10.1093/jac/dks069. Epub 2012 Mar 7.
8
Ceftaroline fosamil: a novel broad-spectrum cephalosporin.头孢洛林酯：一种新型广谱头孢菌素。
Drugs Today (Barc). 2010 Oct;46(10):743-55. doi: 10.1358/dot.2010.46.10.1519172.
9
Resistance and the management of complicated skin and skin structure infections: the role of ceftobiprole.耐药与复杂性皮肤及皮肤结构感染的管理：头孢托罗的作用。
Ther Clin Risk Manag. 2010 Oct 5;6:485-95. doi: 10.2147/TCRM.S5823.
10
A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes.一株耐甲氧西林金黄色葡萄球菌 mecA 阴性株具有高水平的β-内酰胺类药物耐药性，该耐药株含有三个基因突变。
Antimicrob Agents Chemother. 2010 Nov;54(11):4900-2. doi: 10.1128/AAC.00594-10. Epub 2010 Aug 30.
Zotero 插件