Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
Clinical Microbiology and Infectious Diseases Unit, Hospital Universitario La Paz, Madrid, Spain.
Eur J Clin Microbiol Infect Dis. 2021 Sep;40(9):2029-2032. doi: 10.1007/s10096-021-04219-0. Epub 2021 Mar 8.
We report a case of osteomyelitis due to methicillin-resistant Staphylococcus aureus (MRSA) that is also non-susceptible to vancomycin, dalbavancin, ceftaroline, and ceftobiprole, in the absence of exposure to the latter three antibiotics. It was isolated from a patient with a 26-year history of cranial surgeries and episodes of osteomyelitis. Whole-genome sequencing was performed. It was found to belong to ST247 and the mecA gene was detected within the SSCmec type I (1B) gene cassette that lacked the E447K mutation known to produce resistance to ceftobiprole and ceftaroline. However, mutations in other genes related to resistance to these antibiotics were found.
我们报告了一例由耐甲氧西林金黄色葡萄球菌（MRSA）引起的骨髓炎病例，该病例对万古霉素、达巴万星、头孢洛林和头孢比普也不敏感，而且没有接触过后三种抗生素。它是从一名有 26 年颅骨手术和骨髓炎病史的患者中分离出来的。进行了全基因组测序。发现它属于 ST247，mecA 基因位于 SSCmec Ⅰ型（1B）基因盒内，该基因盒缺乏已知对头孢比普和头孢洛林产生耐药性的 E447K 突变。然而，发现了与这些抗生素耐药性相关的其他基因的突变。
