反三碘甲状腺原氨酸（rT3）与肌苷酸脱氢酶抑制剂对正常及21三体淋巴细胞培养物作用的相关性。
Correlation between the effects of rT3 and IMP dehydrogenase inhibitors on normal and trisomic 21 lymphocyte cultures.
作者信息
Peeters M, Réthoré M O, de Kermadec S, Lejeune J
机构信息
Centre de Recherches Génétique Humaine et Maladies de l'Intelligence,Institut de Progenèse, Paris.
出版信息
Ann Genet. 1989;32(4):211-3.
3,3'5'-triiodothyronine (rT3) levels have been documented to be low in patients with Down syndrome but the metabolic implications of this finding remain unknown. A highly significant correlation was found between the in vitro variations of the mitotic index in lymphocyte cultures when rT3 or known inhibitors of inosine monophosphate dehydrogenase: mycophenolic acid, 6-mercaptopurine or 2-3-diphosphoglycerate were added. No significant difference was found between the response of trisomy 21 or normal lymphocytes. The finding suggests that rT3 may be a physiological modulator of inosine monophosphate dehydrogenase. The implications on cellular differentiation are discussed.
已有文献记载，唐氏综合征患者的3,3',5'-三碘甲状腺原氨酸（反三碘甲状腺原氨酸，rT3）水平较低，但这一发现的代谢意义仍不明确。当添加rT3或已知的肌苷单磷酸脱氢酶抑制剂：霉酚酸、6-巯基嘌呤或2,3-二磷酸甘油酸时，在淋巴细胞培养物中发现有丝分裂指数的体外变化之间存在高度显著的相关性。21三体淋巴细胞或正常淋巴细胞的反应之间未发现显著差异。这一发现表明，rT3可能是肌苷单磷酸脱氢酶的一种生理调节剂。文中讨论了其对细胞分化的影响。
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