MCP-1基因-2518A/G多态性与四川汉族人群肺结核发病风险的相关性
The association between the -2518A/G polymorphism in the MCP-1 gene and the risk of pulmonary tuberculosis in Sichuan Chinese population.
作者信息
Chen L M, Tong X, Li X B, Wu Z J, Zhang Y G
机构信息
West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China.
出版信息
Eur Rev Med Pharmacol Sci. 2015 Feb;19(4):563-6.
OBJECTIVE
The -2518A/G polymorphism in the Monocyte chemotactic protein-1 (MCP-1) gene may play an important role in regulating immunological reactions and may be associated with pulmonary tuberculosis (PTB). However, the relationship for the populations in Sichuan province of China remains unknown. The objective of the current study was to analysis that association.
PATIENTS AND METHODS
A total of 386 PTB patients and 398 controls were recruited. The genotypes were identified using PCR-RFLP and sequencing method. Data was analyzed using SPSS 11.0 software.
RESULTS
Significant association was found between the polymorphism and the risk of PTB: AG vs. AA: OR = 1.37, 95% CI = 0.98-1.92 and p = 0.06; GG vs. AA: OR = 1.69, 95% CI = 1.14-2.50 and p = 0.009; AG+GG vs. AA: OR = 1.47, 95% CI = 1.07-2.01 and p = 0.02; G vs. A: OR = 1.31, 95% CI = 1.08-1.60 and p = 0.007.
CONCLUSIONS
The current study suggested that the 2518A/G polymorphism in the MCP-1 gene was associated with risk of PTB in population of Sichuan province in China.
目的
单核细胞趋化蛋白-1（MCP-1）基因中的-2518A/G多态性可能在调节免疫反应中起重要作用，并且可能与肺结核（PTB）相关。然而，中国四川省人群的这种关系仍不清楚。本研究的目的是分析这种关联。
患者与方法
共招募了386例肺结核患者和398例对照。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和测序方法鉴定基因型。使用SPSS 11.0软件进行数据分析。
结果
发现该多态性与肺结核风险之间存在显著关联：AG与AA比较：比值比（OR）=1.37，95%置信区间（CI）=0.98-1.92，p=0.06；GG与AA比较：OR=1.69，95%CI=1.14-2.50，p=0.009；AG+GG与AA比较：OR=1.47，95%CI=1.07-2.01，p=0.02；G与A比较：OR=1.31，95%CI=1.08-1.60，p=0.007。
结论
本研究表明，MCP-1基因中的2518A/G多态性与中国四川省人群的肺结核风险相关。
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