基质金属蛋白酶-2（MMP-2）和基质金属蛋白酶-9（MMP-9）启动子区域的功能多态性与阻塞性睡眠呼吸暂停易感性
Functional polymorphisms in the promoter region of MMP-2 and MMP-9 and susceptibility to obstructive sleep apnea.
作者信息
Cao Chao, Wu Bin, Wu Yanping, Yu Yiming, Ma Hongying, Sun Shifang, Zhang Qiaoli, Ding Qunli, Chen Li, Deng Zaichun
机构信息
1] Department of Respiratory Medicine, Affiliated Hospital of School of Medicine, Ningbo University, Ningbo 315020, China [2] Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Department of Respiratory and Critical Care Medicine, Affiliated Hospital, Institute of Respiratory Diseases, Guangdong Medicine College, Zhanjiang 524000, China.
出版信息
Sci Rep. 2015 Mar 10;5:8966. doi: 10.1038/srep08966.
Genetic susceptibility to obstructive sleep apnea (OSA) has been a research focus in the scientific community in the past few years. In this study, we recruited 375 subjects to investigate whether functional polymorphisms in the promoter region of matrix metalloproteinase (MMP)-2 (-1306C/T) and MMP-9 (-1562C/T) increased susceptibility to OSA. Our study showed no significant association between MMP-2 -1306C/T polymorphism and risk of OSA (T vs. C: OR = 1.01, 95% CI = 0.67-1.52; P = 0.97). Compared with the MMP-9 -1562C allele, the -1562T allele was associated with increased risk of OSA (T vs. C: OR = 1.56, 95% CI = 1.02-2.39; P = 0.04). However, neither MMP-2 -1306C/T nor MMP-9 -1562C/T polymorphism was found to be associated with severity of the disease. Our study suggested that the MMP-2 -1306C/T polymorphism was not associated with OSA susceptibility, whereas the MMP-9 -1562T allele was associated with increased risk of OSA.
在过去几年中，阻塞性睡眠呼吸暂停（OSA）的遗传易感性一直是科学界的研究重点。在本研究中，我们招募了375名受试者，以调查基质金属蛋白酶（MMP）-2（-1306C/T）和MMP-9（-1562C/T）启动子区域的功能多态性是否会增加OSA易感性。我们的研究表明，MMP-2 -1306C/T多态性与OSA风险之间无显著关联（T vs. C：OR = 1.01，95%CI = 0.67-1.52；P = 0.97）。与MMP-9 -1562C等位基因相比，-1562T等位基因与OSA风险增加相关（T vs. C：OR = 1.56，95%CI = 1.02-2.39；P = 0.04）。然而，未发现MMP-2 -1306C/T和MMP-9 -1562C/T多态性与疾病严重程度相关。我们的研究表明，MMP-2 -1306C/T多态性与OSA易感性无关，而MMP-9 -1562T等位基因与OSA风险增加相关。
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