Zeng Shiying, Li Shisheng, Tang Qinglai, Tuerdi Ayinuer, Tong Xinying, Tang Xiaojun, Yin Danhui, Li Mengmeng, Yang Qian
Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital Central South University Changsha Hunan China.
Nephrology Institute Central South University Changsha Hunan China.
Laryngoscope Investig Otolaryngol. 2022 Apr 25;7(3):885-893. doi: 10.1002/lio2.796. eCollection 2022 Jun.
Patients with obstructive sleep apnea (OSA) are more likely to suffer from hypertension. At the same time, the serum levels of matrix metalloproteinase-9 (MMP-9) and nitric oxide (NO) in patients with OSA are also changed in OSA patients. We investigated the correlation between serum levels of MMP-9, NO in patients with OSA and their association with hypertension in those patients, and the effects of continuous positive airway pressure therapy (CPAP) on these serum biomarkers and blood pressure.
Serum MMP-9 and NO levels and blood pressure of 57 patients with newly diagnosed OSA and 30 controls were measured; among them, 30 patients with moderate to severe OSA underwent 3-month CPAP treatment.
In comparison to the control group, the MMP-9 serum levels were higher (232.8 ± 103.2 ng/ml versus 161.6 ± 56.5 ng/ml, < .001*), there was no statistical significance difference among serum NO (26.7 ± 9.1 IU/ml versus 31.0 ± 11.7 IU/ml, = .06), and MMP-9 was negatively correlated to NO, especially in patients with hypertension ( = -.644, = .02*). MMP-9, NO, and blood pressure were significantly recovered in the patients with OSA after CPAP treatment for 3 months ( < .05*).
The MMP-9 level and the NO level were altered in OSA patients. The relationship between the two especially in patients with hypertension suggests the potential mechanism of OSA-induced hypertension.
阻塞性睡眠呼吸暂停（OSA）患者更易患高血压。同时，OSA患者血清基质金属蛋白酶-9（MMP-9）和一氧化氮（NO）水平也会发生变化。我们研究了OSA患者血清MMP-9、NO水平与其高血压之间的相关性，以及持续气道正压通气治疗（CPAP）对这些血清生物标志物和血压的影响。
测量57例新诊断的OSA患者和30例对照者的血清MMP-9、NO水平及血压；其中30例中重度OSA患者接受了3个月的CPAP治疗。
与对照组相比，MMP-9血清水平较高（232.8±103.2 ng/ml对161.6±56.5 ng/ml，P<0.001*），血清NO水平差异无统计学意义（26.7±9.1 IU/ml对31.0±11.7 IU/ml，P = 0.06），且MMP-9与NO呈负相关，尤其是高血压患者（r = -0.644，P = 0.02*）。OSA患者经3个月CPAP治疗后，MMP-9、NO及血压均显著恢复（P<0.05*）。
OSA患者MMP-9水平和NO水平发生改变。二者之间的关系，尤其是高血压患者，提示了OSA诱发高血压的潜在机制。
