Wang Shuai, Wang Zhou
Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
J Gastroenterol Hepatol. 2015 Jul;30(7):1123-33. doi: 10.1111/jgh.12940.
HOX transcript antisense intergenic RNA (HOTAIR), a well-known long noncoding RNA, has been found to play significant roles in several tumors. However, the clinical application value of HOTAIR in digestive system malignancies remains to be clarified. We aimed to explore comprehensively the potential role of HOTAIR as a prognostic indicator in digestive system malignancies.
Systematic search was performed in Pubmed, Embase, Cochrane Library, and Web of Science until July 5, 2014. A quantitative meta-analysis was conducted with standard statistical methods for eligible papers on the prognostic value of HOTAIR in digestive system cancers.
A total of 1059 patients from 13 studies were included in the meta-analysis. A significant association was found between HOTAIR abundance and poor overall survival (OS) of patients with digestive system malignancies, with pooled hazard ratio (HR) of 2.587 (95% confidence interval [CI]: 2.054-3.259, P < 0.001). By combining HRs from Cox multivariate analyses, we found HOTAIR was an independent prognostic factor for OS without obvious heterogeneity (HR: 2.405, 95% CI: 1.883-3.0722, P < 0.001). Subgroup analysis showed that tumor type, histology type, region, publication year, sample size, and quality score did not alter the predictive value of HOTAIR as an independent factor for survival. Meta-regression and sensitivity analysis both suggested the reliability of our findings. A slight publication bias was observed. After adjustment by nonparametric "trim-and-fill" method, the corrected HRs had no significant change.
HOTAIR could be exploited as a novel prognostic biomarker for patients with digestive system malignancies.
HOX转录本反义基因间RNA（HOTAIR）是一种著名的长链非编码RNA，已发现其在多种肿瘤中发挥重要作用。然而，HOTAIR在消化系统恶性肿瘤中的临床应用价值仍有待阐明。我们旨在全面探讨HOTAIR作为消化系统恶性肿瘤预后指标的潜在作用。
截至2014年7月5日，在PubMed、Embase、Cochrane图书馆和科学网进行系统检索。采用标准统计方法对符合条件的关于HOTAIR在消化系统癌症预后价值的论文进行定量荟萃分析。
荟萃分析共纳入13项研究的1059例患者。发现HOTAIR丰度与消化系统恶性肿瘤患者的总体生存期（OS）差之间存在显著关联，合并风险比（HR）为2.587（95%置信区间[CI]：2.054 - 3.259，P < 0.001）。通过合并Cox多变量分析的HR值，我们发现HOTAIR是OS的独立预后因素，且无明显异质性（HR：2.405，95% CI：1.883 - 3.0722，P < 0.001）。亚组分析表明，肿瘤类型、组织学类型、地区、发表年份、样本量和质量评分均未改变HOTAIR作为生存独立因素的预测价值。荟萃回归和敏感性分析均提示我们研究结果的可靠性。观察到轻微的发表偏倚。采用非参数“修剪填充”方法调整后，校正后的HR值无显著变化。
HOTAIR可作为消化系统恶性肿瘤患者的一种新型预后生物标志物。
