Xi Wenna, Song Wei
Department of Hepatology, Second Affiliated Hospital of Nanchang University, Nanchang 330000, China
Department of Hepatobiliary Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330000, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Dec 28;41(12):1352-1357. doi: 10.11817/j.issn.1672-7347.2016.12.017.
To systematically review the prognostic value regarding the expression of long non-coding RNA (lncRNA) Hox transcript antisense intergenic RNA (HOTAIR) in patients with cancer. Methods: Databases including The Cochrane Library, EMBASE, MEDLINE, and PubMed were searched to collect English literature on the correlation between lncRNA HOTAIR expression and overall survival in tumors. The retrieval time was from inception to September 2015. After data were extracted, a Meta-analysis was performed using RevMan 5.3 software. Results: A total of 17 studies were included, which was involved in 1 639 patients. The Meta-analysis showed that high expression of HOTAIR could predict poor overall survival in cancer (HR: 2.39, 95% CI 2.01-2.86, P<0.001). High expression of HOTAIR could also predict poor overall survival both in digestive tumor (HR: 2.51, 95% CI 2.02-3.11, P<0.001) and non-digestive tumor (HR: 2.17, 95% CI 1.59-2.98, P<0.001). Moreover, overexpression of HOTAIR was found to be significantly associated with recurrence-free survival. Conclusion: The overexpression of lncRNA HOTAIR might be associated with poor prognosis in patients with cancer.
系统评价长链非编码RNA（lncRNA）Hox转录本反义基因间RNA（HOTAIR）表达对癌症患者的预后价值。
检索Cochrane图书馆、EMBASE、MEDLINE和PubMed等数据库，收集关于lncRNA HOTAIR表达与肿瘤总生存相关性的英文文献。检索时间从建库至2015年9月。提取数据后，使用RevMan 5.3软件进行Meta分析。
共纳入17项研究，涉及1639例患者。Meta分析显示，HOTAIR高表达可预测癌症患者总生存较差（HR：2.39，95%CI 2.01 - 2.86，P<0.001）。HOTAIR高表达在消化道肿瘤（HR：2.51，95%CI 2.02 - 3.11，P<0.001）和非消化道肿瘤（HR：2.17，95%CI 1.59 - 2.98，P<0.001）中均提示总生存较差。此外，发现HOTAIR过表达与无复发生存显著相关。
lncRNA HOTAIR过表达可能与癌症患者预后不良相关。
