女性月经与生殖史、外源性性激素的使用与甲状腺癌风险：一项前瞻性研究的荟萃分析
Menstrual and reproductive history and use of exogenous sex hormones and risk of thyroid cancer among women: a meta-analysis of prospective studies.
作者信息
Caini Saverio, Gibelli Bianca, Palli Domenico, Saieva Calogero, Ruscica Massimilano, Gandini Sara
机构信息
Unit of Molecular and Nutritional Epidemiology, Institute for Cancer Research and Prevention (ISPO), Via delle Oblate 2, 50139, Florence, Italy,
出版信息
Cancer Causes Control. 2015 Apr;26(4):511-8. doi: 10.1007/s10552-015-0546-z. Epub 2015 Mar 10.
PURPOSE
Thyroid cancer has a higher incidence in women than in men, and it has been hypothesized that hormonal factors may explain such disparity. We performed a meta-analysis of observational prospective studies to investigate the association between menstrual and reproductive variables and exogenous hormone use and the risk of thyroid cancer among women.
METHODS
We calculated summary relative risks and 95% confidence intervals (95% CI) using random effect models.
RESULTS
Overall, 5,434 thyroid cancer cases from twenty-four papers were included. Increasing age at first pregnancy/birth (SRR 1.56, 95% CI 1.01-2.42) and hysterectomy (SRR 1.43, 95% CI 1.15-1.78) were associated with thyroid cancer risk. Women that were in menopause at enrolment had a reduced thyroid cancer risk (SRR 0.79, 95% CI 0.62-1.01). No other menstrual, reproductive, and hormonal variable was associated with thyroid cancer risk.
CONCLUSIONS
Menstrual and reproductive factors may play a role in the etiology of thyroid cancer, possibly through the mediation of estrogen receptors.
目的
甲状腺癌在女性中的发病率高于男性，据推测激素因素可能解释这种差异。我们对观察性前瞻性研究进行了荟萃分析，以调查月经和生殖变量、外源性激素使用与女性甲状腺癌风险之间的关联。
方法
我们使用随机效应模型计算汇总相对风险和95%置信区间（95%CI）。
结果
总体而言，纳入了来自24篇论文的5434例甲状腺癌病例。首次怀孕/生育年龄增加（SRR 1.56，95%CI 1.01 - 2.42）和子宫切除术（SRR 1.43，95%CI 1.15 - 1.78）与甲状腺癌风险相关。入组时处于更年期的女性甲状腺癌风险降低（SRR 0.79，95%CI 0.62 - 1.01）。没有其他月经、生殖和激素变量与甲状腺癌风险相关。
结论
月经和生殖因素可能在甲状腺癌的病因中起作用，可能是通过雌激素受体的介导。
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