Ricci Francesco, Paradisi Andrea, Fossati Barbara, Mancini Monica, Curatolo Pietro, Guerriero Cristina, Capizzi Rodolfo
Department of Dermatology, Catholic University of Sacred Heart, Rome, Italy.
Department of Dermatology, Health Services Research Unit, Istituto Dermopatico dell'Immacolata - Istituto di ricovero e cura a carattere scientifico, Rome, Italy.
Dermatol Ther. 2015 Jul-Aug;28(4):230-4. doi: 10.1111/dth.12214. Epub 2015 Mar 5.
Nonmelanoma skin cancers (NMSCs) are the most common type of skin tumor, representing about one-third of all malignancies diagnosed worldwide each year. Cutaneous squamous cell carcinoma (cSCC) is the second most common form of NMSCs and the risk of cSCC invasiveness should be assessed on the basis of tumor size, anatomical location, and histological subtype. Although most cSCCs are early diagnosed and successfully treated, in a small percentage of patients with giant cSCC (maximum diameter >5 cm), metastases may occur; treatment options are limited and not really effective. We report the case of a giant metastatic cSCC that had been neglected for more than 20 years. Radiotherapy or surgery were not feasible and polichemotherapy (cisplatin, 5-fluorouracil and paclitaxel) was not effective. Therefore, the patient was treated with palliative electrochemotherapy (ECT) achieving a partial reduction of cutaneous metastasis and pain relief but unfortunately the patient died 3 months after the second ECT treatment.
非黑色素瘤皮肤癌（NMSCs）是最常见的皮肤肿瘤类型，约占全球每年诊断出的所有恶性肿瘤的三分之一。皮肤鳞状细胞癌（cSCC）是NMSCs的第二常见形式，应根据肿瘤大小、解剖位置和组织学亚型评估cSCC侵袭的风险。尽管大多数cSCC能早期诊断并成功治疗，但在一小部分患有巨大cSCC（最大直径>5厘米）的患者中，可能会发生转移；治疗选择有限且效果不佳。我们报告了一例被忽视超过20年的巨大转移性cSCC病例。放疗或手术不可行，多药化疗（顺铂、5-氟尿嘧啶和紫杉醇）也无效。因此，该患者接受了姑息性电化学疗法（ECT），实现了皮肤转移灶部分缩小并缓解了疼痛，但不幸的是，患者在第二次ECT治疗3个月后死亡。
