Department of Surgical Oncology, IRCCS San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
J Surg Oncol. 2014 Mar;109(3):270-4. doi: 10.1002/jso.23481. Epub 2013 Oct 28.
Electrochemotherapy (ECT) is technique for local control of skin metastasis. This study is primarily aimed at assessing the clinical activity of ECT in a prospective cohort of patients, and evaluating the association between primary tumor histology, number of metastatic lesions and size of tumor deposits and objective response rate.
Thirty-nine patients with skin metastases from melanoma and other tumors underwent intravenous bleomycin ECT with palliative intent. No serious adverse events (SAE) or CTC grade 3 or 4 were observed. Overall response rate (ORR) was 66.6%. Response rate significantly correlated at univariate analysis both with the number (< or >10) and the size (< or >2 cm) of metastases. No relationship was observed for the histology of primary tumor. At multivariate analysis the size of the nodules under 2 cm was associated with a positive response and the correlation was statistically significant.
ORR was 66.6% and all patients obtained a subjective clinical benefit from the treatment with minimal side effects. The most suitable patients were the ones with nodules <2 cm.
电化疗（ECT）是一种用于皮肤转移局部控制的技术。本研究主要旨在评估 ECT 在一组前瞻性患者中的临床疗效，并评估原发肿瘤组织学、转移病灶数量和肿瘤沉积大小与客观缓解率之间的关系。
39 例皮肤转移性黑色素瘤和其他肿瘤患者接受了姑息性静脉注射博来霉素 ECT。未观察到严重不良事件（SAE）或 CTC 3 或 4 级。总体缓解率（ORR）为 66.6%。在单变量分析中，缓解率与转移灶的数量（<或> 10 个）和大小（<或> 2 cm）显著相关。原发肿瘤的组织学没有观察到相关性。在多变量分析中，<2 cm 的结节大小与阳性反应相关，且相关性具有统计学意义。
ORR 为 66.6%，所有患者均获得了最小副作用的治疗带来的主观临床获益。最适合的患者是结节<2 cm 的患者。
