Fernandez Genaro, Lee Junsoo Alex, Liu Lynn C, Gassler John P
University of Rochester Cardiology Division, Strong Memorial Hospital, University of Rochester Medical Center, 601 Elmwood Ave, Box 679-C, Rochester, NY, 14642, USA.
Curr Hypertens Rep. 2015 Mar;17(3):19. doi: 10.1007/s11906-014-0531-z.
Hypertension is a complex syndrome that increases the risk of developing other medical comorbidities and interacts with other medical conditions to increase the risk of target end-organ damage such as cardiovascular disease, stroke, and renal disease. Hypertension remains under-recognized and poorly controlled in the USA and worldwide. In some patients, hypertension is resistant to optimal medical therapy. Over the last few decades, there has been an increasing understanding of the role of the sympathetic nervous system in the development and maintenance of hypertension. This update reviews the physiology and role of the sympathetic nervous system in hypertension and pharmacological and interventional treatments directed at nervous system involvement in secondary hypertension.
高血压是一种复杂的综合征，它会增加患其他合并症的风险，并与其他疾病相互作用，增加诸如心血管疾病、中风和肾病等靶器官终末损伤的风险。在美国乃至全球，高血压仍未得到充分认识且控制不佳。在一些患者中，高血压对最佳药物治疗具有抗性。在过去几十年里，人们对交感神经系统在高血压发生和维持中的作用有了越来越多的认识。本综述回顾了交感神经系统在高血压中的生理学和作用，以及针对继发性高血压中神经系统参与情况的药物和介入治疗。
