Zhang Wen-Zhen, Xia Tian, Yang Xu-Tong, Lu Xiao-Bing
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012, P. R. China.
Chem Commun (Camb). 2015 Apr 11;51(28):6175-8. doi: 10.1039/c5cc01530h.
The oxazolidine-2,4-dione motif is found frequently in biologically important compounds. A tandem phosphorus-mediated carboxylative condensation of primary amines and α-ketoesters/base-catalyzed cyclization reaction have been developed. These processes provide a novel and convenient access to various oxazolidine-2,4-diones in a one-pot fashion using atmospheric carbon dioxide and readily available substrates under very mild and transition-metal-free conditions.
恶唑烷-2,4-二酮结构单元在具有生物学重要性的化合物中经常出现。已开发出一种由磷介导的伯胺与α-酮酯的串联羧基化缩合反应以及碱催化的环化反应。这些过程提供了一种新颖且便捷的方法，可在非常温和且无过渡金属的条件下，利用大气中的二氧化碳和易于获得的底物，以一锅法制备各种恶唑烷-2,4-二酮。
