酪氨酰-促黑素细胞激素-1（Tyr-MIF-1）和纳洛酮在两种涉及苯二氮䓬类药物的动物模型中的不同作用。

Differential effects of Tyr-MIF-1 and naloxone in two animal models involving benzodiazepine.

作者信息

Kastin A J, Schwartzenburg D, Tsui L, Miller L G, Olson G A, Olson R D

机构信息

VA Medical Center, New Orleans, LA 70146.

出版信息

Brain Res Bull. 1989 Dec;23(6):443-6. doi: 10.1016/0361-9230(89)90187-1.

DOI:10.1016/0361-9230(89)90187-1

PMID:2575442

Abstract

It has been shown previously that the endogenous brain peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) can act as an antiopiate and can also increase binding and function at the GABAA/benzodiazepine receptor complex. We now describe the effects of this tetrapeptide in two models in which the antiopiate naloxone has been reported to decrease the activity of benzodiazepines. Unlike naloxone, Tyr-MIF-1 and MIF-1 neither prevented chlordiazepoxide-induced locomotor hyperactivity in mice on a tilting floor nor suppressed chlordiazepoxide-induced eating in rats. Thus, in these two systems, Try-MIF-1 did not act as an antiopiate or alter the effects of a benzodiazepine, indicating a selectivity in the actions of Tyr-MIF-1.

摘要

先前的研究表明，内源性脑肽酪氨酰-促黑素细胞激素-1（Tyr-Pro-Leu-Gly-NH2）可作为一种抗阿片剂，还能增强GABAA/苯二氮䓬受体复合物的结合及功能。我们现在描述这种四肽在两种模型中的作用，在这两种模型中，据报道抗阿片剂纳洛酮可降低苯二氮䓬类药物的活性。与纳洛酮不同，酪氨酰-促黑素细胞激素-1和促黑素细胞激素-1既不能阻止氯氮卓引起的小鼠在倾斜地板上的运动性活动亢进，也不能抑制氯氮卓引起的大鼠进食。因此，在这两个系统中，酪氨酰-促黑素细胞激素-1并未起到抗阿片剂的作用，也未改变苯二氮䓬类药物的效果，这表明酪氨酰-促黑素细胞激素-1的作用具有选择性。