Hagan M M, Moss D E
Department of Psychology, University of Texas at El Paso 79968-0553.
Peptides. 1994;15(2):243-5. doi: 10.1016/0196-9781(94)90009-4.
Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) and MIF-1 (Pro-Leu-Gly-NH2) act as opiate antagonists in various behavioral systems including ingestion. Central injection of peptide YY (PYY) elicits a powerful feeding response in satiated rats, and the opioid antagonist naloxone decreases eating in a variety of conditions including PYY-stimulated eating. Therefore, the aim of this study was to examine the effects of Tyr-MIF-1 and MIF-1 as opiate antagonists on a naloxone-sensitive PYY model of hyperphagia. Naloxone at doses of 1.0 and 10.0 mg/kg, SC, decreased hyperphagia induced by 2.4 micrograms PYY injected in the PVN. MIF-1 and Tyr-MIF-1 had no effect on PYY-induced eating at doses comparable to naloxone (0.1 to 10.0 mg/kg, IP). These results suggest that in this model of eating behavior, Tyr-MIF-1 and MIF-1 do not act as opiate antagonists.
酪氨酰-促黑素细胞激素-1（酪氨酰-脯氨酰-亮氨酰-甘氨酰胺）和促黑素细胞激素-1（脯氨酰-亮氨酰-甘氨酰胺）在包括摄食在内的多种行为系统中作为阿片拮抗剂发挥作用。向饱足的大鼠脑室内注射肽YY（PYY）会引发强烈的进食反应，而阿片拮抗剂纳洛酮在包括PYY刺激进食在内的多种情况下都会减少进食。因此，本研究的目的是研究酪氨酰-促黑素细胞激素-1和促黑素细胞激素-1作为阿片拮抗剂对纳洛酮敏感的PYY诱导的食欲亢进模型的影响。皮下注射剂量为1.0和10.0mg/kg的纳洛酮可减少由向室旁核注射2.4微克PYY诱导的食欲亢进。促黑素细胞激素-1和酪氨酰-促黑素细胞激素-1在与纳洛酮相当的剂量（0.1至10.0mg/kg，腹腔注射）下对PYY诱导的进食没有影响。这些结果表明，在这个进食行为模型中，酪氨酰-促黑素细胞激素-1和促黑素细胞激素-1不作为阿片拮抗剂起作用。
