泰舒达对亨廷顿舞蹈症患者的影响。

Effects of terguride in patients with Huntington's disease.

作者信息

Stocchi F, Carta A, Berardelli A, Antonini A, Argenta M, Formica A, Agnoli A

机构信息

Department of Neuroscience, La Sapienza University, Rome, Italy.

出版信息

Clin Neuropharmacol. 1989 Oct;12(5):435-9. doi: 10.1097/00002826-198910000-00008.

DOI:10.1097/00002826-198910000-00008

PMID:2575450

Abstract

trans-Dihydrolisuride, a partial dopamine receptor agonist, was tested for its effects on chorea in a double-blind, crossover clinical study in 10 patients with Huntington's disease. In eight patients, a neurophysiological evaluation was also performed. No reduction in choreic movements or improvement in voluntary movement performance was observed. However, in some patients, there was a slight improvement in patients' alertness and a reduction of the movement reaction time.

摘要

反式二氢麦角隐亭是一种多巴胺受体部分激动剂，在一项针对10名亨廷顿舞蹈症患者的双盲交叉临床研究中，对其治疗舞蹈症的效果进行了测试。其中8名患者还接受了神经生理学评估。未观察到舞蹈样动作减少或自主运动表现改善。然而，部分患者的警觉性略有提高，运动反应时间缩短。