Atanasovska Stojanovska Aneta, Popovska Mirjana, Muratovska Ilijana, Mitic Kristina, Stefanovska Emilija, Radojkova Nikolovska Vera
Department of Oral Pathology and Periodontology, University Dental Clinical Centre - Skopje, Faculty of Dentistry, Ss. Cyril and Methodius University, Skopje, R. Macedonia.
Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2014;35(3):195-202.
Recurrent aphthous stomatitis (RAS) is a quite frequent, painful, ulcerative disease that affects the lining of the oral cavity and has an unknown etiology. The aim of this article is to examine the impact of the medication proaftol on epithelization speed and severity of pain in patients with RAS. In this randomized, double-blind, placebo-controlled study respondents were divided into two groups where one group was treated with proaftol spray and the other with a placebo. Aphthae considered for treatment had a diameter of 5-6 mm. The participants were given instruction on the use of the spray, two sprayings on the place of the aphtae 3-4 times a day. We examined two parameters in the symptomatology of RAS-lesion size (mm) and pain intensity (noted on four subjective levels: 0-no pain, 1-discomfort, 2-moderate pain, 3-severe pain). These parameters were noted on the baseline, the third, the fifth and the eighth days of examination.
A significant faster reduction of the dimension of aphthous ulcers in patients treated with proaftol 3rd day p<0.001, 5th day p<0.0006, 8th day full epithelization in the control group. The magnitude of pain in the experimental compared with the control group on 3rd, 5th and 8th day was also significantly reduced: p<0.0001, p<0.007, p<0.007 respectively.
The use of proaftol positively influences the rate of epithelization and reduction of subjective feeling of pain in patients with RAS. The action of propolis should be the goal of studies with a larger number of subjects.
复发性阿弗他口炎（RAS）是一种相当常见的、疼痛性溃疡性疾病，影响口腔黏膜，病因不明。本文旨在研究药物普罗夫托尔对RAS患者上皮化速度和疼痛严重程度的影响。在这项随机、双盲、安慰剂对照研究中，受试者被分为两组，一组用普罗夫托尔喷雾剂治疗，另一组用安慰剂治疗。纳入治疗的口疮直径为5 - 6毫米。参与者接受了喷雾剂使用指导，每天在口疮处喷3 - 4次，每次喷两下。我们在RAS症状学中检查了两个参数——病损大小（毫米）和疼痛强度（根据四个主观等级记录：0级 - 无疼痛，1级 - 不适，2级 - 中度疼痛，3级 - 重度疼痛）。这些参数在检查的基线、第3天、第5天和第8天记录。
用普罗夫托尔治疗的患者，口疮溃疡尺寸在第3天（p<0.001）、第5天（p<0.0006）显著更快减小，第8天对照组完全上皮化。与对照组相比，试验组在第3天、第5天和第8天的疼痛程度也显著降低：分别为p<0.0001、p<0.007、p<0.007。
使用普罗夫托尔对RAS患者的上皮化速度和主观疼痛感受的减轻有积极影响。蜂胶的作用应成为更多受试者研究的目标。
