Sung Soo-Hyun, Choi Gwang-Ho, Lee Nam-Woo, Shin Byung-Cheul
Department of Policy Development, National Development Institute of Korean Medicine, Seoul 04554, Republic of Korea.
School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Evid Based Complement Alternat Med. 2017;2017:8025752. doi: 10.1155/2017/8025752. Epub 2017 Feb 6.
The aim of this review is to provide the available evidence on the external use of propolis (EUP) for oral, skin, and genital diseases. We searched twelve electronic databases for relevant studies up to June 2016. Randomized clinical trials (RCTs) were included and analysed. Of the 286 articles identified, twelve potentially relevant studies met our inclusion criteria. A meta-analysis of two studies on recurrent oral aphthae (ROA) indicated that there were no significant differences in total effective rate (TER) for pain disappearance between EUP and placebo groups (RR = 1.96, 95% CI = 0.97-3.98, and = 0.06). In two studies on skin diseases, the combined treatment of EUP with other interventions revealed significant effects on the duration of treatment or TER. In one study on genital diseases, EUP showed significant differences in genital herpes outcome measures compared to placebo. Our results on the effectiveness of EUP for treating oral, skin, and genital diseases are not conclusive because of the low methodological qualities and small sample sizes. Further well-designed randomized controlled trials, with high quality and large samples for specific disorders, must be conducted to obtain firm conclusions.
本综述的目的是提供有关蜂胶外用（EUP）治疗口腔、皮肤和生殖器疾病的现有证据。我们检索了12个电子数据库，查找截至2016年6月的相关研究。纳入并分析了随机临床试验（RCT）。在识别出的286篇文章中，12项潜在相关研究符合我们的纳入标准。对两项复发性口腔溃疡（ROA）研究的荟萃分析表明，EUP组和安慰剂组在疼痛消失的总有效率（TER）方面无显著差异（RR = 1.96，95% CI = 0.97 - 3.98，P = 0.06）。在两项皮肤病研究中，EUP与其他干预措施联合治疗对治疗持续时间或TER有显著效果。在一项生殖器疾病研究中，与安慰剂相比，EUP在生殖器疱疹结局指标上显示出显著差异。由于方法学质量低和样本量小，我们关于EUP治疗口腔、皮肤和生殖器疾病有效性的结果尚无定论。必须开展进一步设计良好、针对特定疾病高质量且大样本的随机对照试验，以得出确凿结论。
