依达拉奉联合葛根素对黑火药烟雾吸入性肺损伤的保护作用
Protective effects of edaravone combined puerarin on inhalation lung injury induced by black gunpowder smog.
作者信息
Wang Zhengguan, Li Ruibing, Liu Yifan, Liu Xiaoting, Chen Wenyan, Xu Shumin, Guo Yuni, Duan Jinyang, Chen Yihong, Wang Chengbin
机构信息
Department of Clinical Laboratory, Chinese People's Liberation Army General Hospital, Beijing 100853, People's Republic of China; Department of Medical Security, Chinese People's Liberation Army General Hospital, Beijing 100853, People's Republic of China.
Department of Clinical Laboratory, Chinese People's Liberation Army General Hospital, Beijing 100853, People's Republic of China.
出版信息
Int Immunopharmacol. 2015 May;26(1):125-32. doi: 10.1016/j.intimp.2015.02.034. Epub 2015 Mar 6.
OBJECTIVE
The present study aimed to investigate the combined effects of puerarin with edaravone on inhalation lung injury induced by black gunpowder smog.
MATERIALS AND METHODS
Male Wistar rats were divided into five groups (control group, edaravone group, puerarin group, edaravone combined with puerarin group and inhalation group). The severity of pulmonary injuries was evaluated after inducing acute lung injury. Arterial blood gas, inflammatory cytokines, biochemical, parameters, cell counting, W/D weight ratio and histopathology were analyzed. Results in lung tissues, either edaravone or puerarin treatment alone showed significant protective effects against neutrophil infiltration and tissue injury, as demonstrated by myeloperoxidase activity and histopathological analysis (all p<0.05). In addition, combined treatment with both edaravone and puerarin demonstrated additive protective effects on smog-induced lung injury, compared with single treatment.
CONCLUSIONS
Combination of edaravone and puerarin shows promise as a new treatment option for acute lung injury/acute respiratory distress syndrome patients.
目的
本研究旨在探讨葛根素与依达拉奉联合应用对黑火药烟雾吸入性肺损伤的综合影响。
材料与方法
将雄性Wistar大鼠分为五组（对照组、依达拉奉组、葛根素组、依达拉奉联合葛根素组和吸入组）。诱导急性肺损伤后评估肺损伤的严重程度。分析动脉血气、炎性细胞因子、生化参数、细胞计数、湿/干重比和组织病理学。肺组织结果显示，单独使用依达拉奉或葛根素治疗均对中性粒细胞浸润和组织损伤具有显著的保护作用，髓过氧化物酶活性和组织病理学分析证实了这一点（所有p<0.05）。此外，与单一治疗相比，依达拉奉和葛根素联合治疗对烟雾诱导的肺损伤具有相加的保护作用。
结论
依达拉奉和葛根素联合应用有望成为急性肺损伤/急性呼吸窘迫综合征患者的一种新的治疗选择。
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