超声介导的紫杉醇与载氧脂质微泡的破坏用于卵巢癌异种移植瘤的联合治疗
Ultrasound-mediated destruction of paclitaxel and oxygen loaded lipid microbubbles for combination therapy in ovarian cancer xenografts.
作者信息
Liu Li, Chang Shufang, Sun Jiangchuan, Zhu Shenyin, Yin Minyue, Zhu Yi, Wang Zhigang, Xu Ronald X
机构信息
Department of Obstetrics and Gynecology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; Institute of Ultrasound Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing 400016, China.
Department of Obstetrics and Gynecology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
出版信息
Cancer Lett. 2015 May 28;361(1):147-54. doi: 10.1016/j.canlet.2015.02.052. Epub 2015 Mar 6.
We have synthesized multifunctional oxygen and paclitaxel loaded microbubbles (OPLMBs) for ultrasound mediated delivery of combination therapy in an ovarian cancer xenograft model. In comparison with other therapeutic options, intravenous injection of OPLMBs followed by ultrasound mediation yielded a superior therapeutic outcome. Immunohistochemical analyses of the dissected tumor tissue confirmed the increased tumor apoptosis and the reduced VEGF expression after treatment. Western Blot tests further confirmed the decreased expressions of HIF-1α and P-gp. Our experiment suggests that ultrasound mediation of OPLMBs may provide a promising drug delivery strategy for the combination treatment of ovarian cancer.
我们合成了负载多功能氧和紫杉醇的微泡（OPLMBs），用于在卵巢癌异种移植模型中进行超声介导的联合治疗。与其他治疗方案相比，静脉注射OPLMBs后进行超声介导产生了更好的治疗效果。对解剖后的肿瘤组织进行免疫组织化学分析证实，治疗后肿瘤凋亡增加，VEGF表达降低。蛋白质免疫印迹试验进一步证实了HIF-1α和P-gp表达的降低。我们的实验表明，OPLMBs的超声介导可能为卵巢癌的联合治疗提供一种有前景的药物递送策略。
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