Bailey Justin R, Dowd Kimberly A, Snider Anna E, Osburn William O, Mehta Shruti H, Kirk Gregory D, Thomas David L, Ray Stuart C
Division of Infectious Diseases, Department of Medicine.
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
J Infect Dis. 2015 Sep 15;212(6):914-23. doi: 10.1093/infdis/jiv139. Epub 2015 Mar 9.
Human immunodeficiency virus (HIV) infection leads to lower rates of hepatitis C virus (HCV) clearance after acute infection, higher HCV viremia, and accelerated progression of HCV-related fibrosis. The mechanisms underlying this acceleration of HCV progression by HIV are poorly understood, but HIV-induced dysfunction in the anti-HCV humoral immune response may play a role.
To define the effect of HIV coinfection on the anti-HCV antibody response, we measured anti-HCV envelope binding antibody titers, neutralizing antibody (nAb) titers, and nAb breadth of serum from HCV-infected subjects isolated longitudinally before and after incident HIV infection.
A significant reduction in HCV envelope-specific binding antibody and nAb titers was detected in subjects with CD4(+) T-cell counts <350/mm(3) after HIV infection, and subjects with CD4(+) T-cell counts <200/mm(3) also showed a reduction in nAb breadth. Subjects who maintained CD4(+) T-cell counts ≥350/mm(3) displayed little to no decline in antibody levels.
Depletion of CD4(+) T cells by HIV infection results in a global decline in the anti-HCV envelope antibody response, including binding antibody titers, nAb titers, and nAb breadth.
人类免疫缺陷病毒（HIV）感染导致急性感染后丙型肝炎病毒（HCV）清除率降低、HCV病毒血症水平升高以及HCV相关纤维化进展加速。HIV导致HCV进展加速的潜在机制尚不清楚，但HIV诱导的抗HCV体液免疫反应功能障碍可能起了作用。
为了确定HIV合并感染对抗HCV抗体反应的影响，我们检测了在HIV感染前后纵向分离的HCV感染受试者血清中的抗HCV包膜结合抗体滴度、中和抗体（nAb）滴度和nAb广度。
HIV感染后CD4(+) T细胞计数<350/mm(3) 的受试者中检测到HCV包膜特异性结合抗体和nAb滴度显著降低，CD4(+) T细胞计数<200/mm(3) 的受试者nAb广度也降低。CD4(+) T细胞计数维持在≥350/mm(3) 的受试者抗体水平几乎没有下降。
HIV感染导致CD4(+) T细胞耗竭，从而使抗HCV包膜抗体反应全面下降，包括结合抗体滴度、nAb滴度和nAb广度。
