HIV-1 重复感染类似于初次感染。
HIV-1 Superinfection Resembles Primary Infection.
作者信息
Sheward Daniel J, Ntale Roman, Garrett Nigel J, Woodman Zenda L, Abdool Karim Salim S, Williamson Carolyn
机构信息
Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.
Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa Department of Biomedical Laboratory Sciences, College of Medicine and Health Sciences, Kigali, Rwanda.
出版信息
J Infect Dis. 2015 Sep 15;212(6):904-8. doi: 10.1093/infdis/jiv136. Epub 2015 Mar 9.
Abstract
The relevance of superinfection as a model to identify correlates of protection against human immunodeficiency virus (HIV) depends on whether the superinfecting transmission resembles primary infection, which has not been established. Here, we characterize the genetic bottleneck in superinfected individuals for the first time. In all 3 cases, superinfection produced a spike in viral load and could be traced to a single, C-C chemokine receptor 5-tropic founder virus with shorter, less glycosylated variable regions than matched chronic viruses. These features are consistent with primary HIV transmission and provide support for the use of superinfection as a model to address correlates of protection against HIV.
摘要
作为一种用于识别针对人类免疫缺陷病毒（HIV）保护性相关因素的模型，重复感染的相关性取决于重复感染传播是否类似于初次感染，而这一点尚未得到证实。在此，我们首次对重复感染个体中的基因瓶颈进行了表征。在所有3例病例中，重复感染导致病毒载量激增，并且可以追溯到单一的、C-C趋化因子受体5型嗜性的奠基病毒，其可变区比匹配的慢性病毒更短、糖基化程度更低。这些特征与HIV初次传播一致，并为将重复感染作为一种模型来研究针对HIV的保护性相关因素提供了支持。
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Virology. 2014 Aug;462-463:295-8. doi: 10.1016/j.virol.2014.06.016. Epub 2014 Jul 5.
2
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