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[颅内高压与颈静脉血栓形成]

[Intracranial hypertension and jugular vein thrombosis].

作者信息

Konrad J, Vogt R, Helbig H, Oberacher-Velten I

机构信息

Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.

出版信息

Ophthalmologe. 2015 Dec;112(12):1002-5. doi: 10.1007/s00347-015-3248-8.

Abstract

BACKGROUND

Pseudotumor cerebri is an idiopathic increase in intracranial pressure, which commonly affects obese women of fertile age. The diagnostic criteria according to the guidelines of the German Society for Neurology are increased cerebrospinal fluid (CSF) pressure, symptoms of increased CSF pressure, normal results of CSF examination, no relevant medication and a lack of structural and vascular lesions in magnetic resonance imaging (MRI).

CASE REPORT

This article presents the case of a 39-year-old male patient who presented at hospital with visual obscuration and recently occurred double vision. Except for a recently diagnosed thrombosis of the left jugular vein of unknown origin, there was nothing else of note in the medical history. Biomicroscopic examination showed papilledema with hemorrhages and cotton wool spots. The CSF opening pressure was initially > 50 cmH2O. During therapy by lumbar puncture (three times), oral carbonic anhydrase inhibitors and loop diuretics, the abducens nerve palsy and papilledema receded. Anticoagulation therapy (initially with coumarin derivatives, then with low molecular weight heparins) was unsuccessful in eliminating the thrombosis of the jugular vein. Surgical intervention was not recommended by the vascular surgeons.

CONCLUSION

This case report demonstrates the unusual combination of (idiopathic) intracranial hypertension and thrombosis of the jugular vein, which occurred spontaneously and without any detectable coagulation disorders.

摘要

背景

假性脑瘤是一种特发性颅内压升高疾病,常见于育龄肥胖女性。根据德国神经病学学会指南,诊断标准为脑脊液(CSF)压力升高、CSF压力升高的症状、CSF检查结果正常、无相关药物使用史以及磁共振成像(MRI)无结构性和血管性病变。

病例报告

本文介绍了一名39岁男性患者的病例,该患者因视力模糊和近期出现复视而入院。除最近诊断出不明原因的左侧颈静脉血栓形成外,病史无其他异常。生物显微镜检查显示视乳头水肿伴出血和棉絮状斑。CSF初压最初>50cmH2O。在通过腰椎穿刺(三次)、口服碳酸酐酶抑制剂和袢利尿剂进行治疗期间,外展神经麻痹和视乳头水肿消退。抗凝治疗(最初使用香豆素衍生物,然后使用低分子量肝素)未能消除颈静脉血栓形成。血管外科医生不建议进行手术干预。

结论

本病例报告显示了(特发性)颅内高压与颈静脉血栓形成的不寻常组合,该组合自发出现且无任何可检测到的凝血障碍。

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