习惯性咖啡摄入量、基因多态性与2型糖尿病

Habitual coffee intake, genetic polymorphisms, and type 2 diabetes.

作者信息

Lee Jae Kyung, Kim Kyunga, Ahn Younjhin, Yang Mihi, Lee Jung Eun

机构信息

Department of Food and NutritionSookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul 140-742, Republic of KoreaBiostatistics and Clinical Epidemiology CenterSamsung Medical center, 50 Ilwon-dong, Gangnam-gu, Seoul 135-170, Republic of KoreaDivision of Cardiovascular and Rare DiseaseNational Institute of Health, Centers of Biomedical Sciences, Center for Disease Control and Prevention, Chungcheongbuk-do, Republic of KoreaResearch Center for Cell Fate controlCollege of Pharmacy, Sookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul 140-742, Republic of Korea.

出版信息

Eur J Endocrinol. 2015 May;172(5):595-601. doi: 10.1530/EJE-14-0805. Epub 2015 Mar 9.

DOI:10.1530/EJE-14-0805

PMID:25755232

Abstract

BACKGROUND

The association between coffee intake and type 2 diabetes may be modulated by common genetic variation.

OBJECTIVE

The purpose of this study was to examine the association between habitual coffee intake and the risk of type 2 diabetes and to determine whether this association varied by genetic polymorphisms related to type 2 diabetes in Korean adults.

DESIGN AND METHODS

A population-based cohort study over a follow-up of 4 years was conducted. A total of 4077 Korean men and women aged 40-69 years with a normal glucose level at baseline were included. Coffee intake was assessed using a validated food frequency questionnaire, and incident type 2 diabetes or prediabetes was defined by oral glucose tolerance test or fasting blood glucose test. The genomic DNA samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 5.0, and nine single-nucleotide polymorphisms related to type 2 diabetes in East Asian populations were extracted.

RESULTS

A total of 120 cases of type 2 diabetes and 1128 cases of prediabetes were identified. After adjustment for potential confounding factors, we observed an inverse association, but without any clear linear trend, between coffee intake and the combined risk of type 2 diabetes and prediabetes. We found that inverse associations between habitual coffee intake and the combined risk of type 2 diabetes and prediabetes were limited to those with the T-allele (GT/TT) of rs4402960 in IGF2BP2, those with the G-allele (GG/GC) of rs7754840 in CDKAL1, or those with CC of rs5215 in KCNJ11.

CONCLUSION

We found a lower risk of prediabetes and type 2 diabetes combined with coffee intake among individuals with the GT/TT of IGF2BP2 rs4402960, GG/GC of CDKAL1 rs7754840, or CC of KCNJ11 rs5215, which are known to be related to type 2 diabetes in East Asians.

摘要

背景

咖啡摄入量与2型糖尿病之间的关联可能受到常见基因变异的调节。

目的

本研究旨在探讨习惯性咖啡摄入量与2型糖尿病风险之间的关联，并确定这种关联在韩国成年人中是否因与2型糖尿病相关的基因多态性而有所不同。

设计与方法

进行了一项为期4年随访的基于人群的队列研究。纳入了4077名年龄在40 - 69岁、基线血糖水平正常的韩国男性和女性。使用经过验证的食物频率问卷评估咖啡摄入量，并通过口服葡萄糖耐量试验或空腹血糖试验定义新发2型糖尿病或糖尿病前期。基因组DNA样本使用Affymetrix全基因组人类SNP Array 5.0进行基因分型，并提取了与东亚人群2型糖尿病相关的9个单核苷酸多态性。

结果

共识别出120例2型糖尿病病例和1128例糖尿病前期病例。在对潜在混杂因素进行调整后，我们观察到咖啡摄入量与2型糖尿病和糖尿病前期的综合风险之间存在负相关，但无明显线性趋势。我们发现，习惯性咖啡摄入量与2型糖尿病和糖尿病前期的综合风险之间的负相关仅限于那些具有IGF2BP2中rs4402960的T等位基因（GT/TT）、CDKAL1中rs7754840的G等位基因（GG/GC）或KCNJ11中rs5215的CC基因型的个体。