Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Quebec, Canada.
Am J Perinatol. 2012 Aug;29(7):551-6. doi: 10.1055/s-0032-1310527. Epub 2012 Apr 11.
To determine whether early administration of aspirin prevents severe and mild preeclampsia.
A systematic review and meta-analysis of randomized controlled trials were performed. Studies in which women were randomized at or before 16 weeks' gestation to low-dose aspirin versus placebo or no treatment were included. The outcomes of interest were severe preeclampsia and mild preeclampsia. Pooled relative risks with their 95% confidence intervals (CIs) were calculated.
Among 7941 citations retrieved, 352 were completely reviewed and four studies (392 women) fulfilled the inclusion criteria and were analyzed. When compared with controls, aspirin started at ≤16 weeks was associated with a significant reduction in severe (relative risk: 0.22, 95% CI: 0.08 to 0.57) but not mild (relative risk: 0.81, 95% CI: 0.33 to 1.96) preeclampsia.
Low-dose aspirin initiated at or before 16 weeks reduces the risk of severe preeclampsia, but not mild preeclampsia.
确定早期使用阿司匹林是否可预防重度和轻度子痫前期。
系统评价和荟萃分析随机对照试验。纳入的研究对象为妊娠 16 周前随机分为低剂量阿司匹林组与安慰剂或空白对照组的女性。主要结局为重度子痫前期和轻度子痫前期。计算合并相对危险度及其 95%置信区间（CI）。
在检索到的 7941 条参考文献中，352 条进行了完整的评估，4 项研究（392 名女性）符合纳入标准并进行了分析。与对照组相比，16 周内开始使用阿司匹林可显著降低重度子痫前期的风险（相对风险：0.22，95%CI：0.08 至 0.57），但对轻度子痫前期无显著影响（相对风险：0.81，95%CI：0.33 至 1.96）。
16 周内开始使用低剂量阿司匹林可降低重度子痫前期的风险，但不降低轻度子痫前期的风险。
