Tyagi Pankaj, Shah Vinit, Sharma Praveen, Bansal Naresh, Singla Vikas, Kumar Ashish, Arora Anil
Department of Gastroenterology & Hepatology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110 060, India.
J Clin Exp Hepatol. 2014 Jun;4(2):172-4. doi: 10.1016/j.jceh.2013.07.003. Epub 2013 Oct 25.
Melioidosis caused by the environmental Gram-negative bacillus Burkholderia pseudomallei is endemic in northern Australia and Southeast Asia and is being described increasingly from south and west coastal regions of India. Melioidosis is known to have high mortality (14-50%) and the risk factors associated with it are diabetes mellitus and heavy alcohol abuse. Melioidosis primarily presents as pneumonia, genitourinary infection and bacteremia. We present a case of Melioidosis from North India, a 56-year-old diabetic male, presenting with fever and jaundice. His blood culture was positive for the B. pseudomallei. The hepatic involvement was in the form of jaundice with serum bilirubin value of more than 12 mg/dL, hepatic enzymes more than ten times high and without hepatic abscess. He improved with intravenous antibiotics with complete normalization of liver function tests.
由环境革兰氏阴性杆菌伯克霍尔德菌引起的类鼻疽在澳大利亚北部和东南亚呈地方流行,并且越来越多地出现在印度南部和西部沿海地区。已知类鼻疽死亡率很高(14%-50%),与之相关的危险因素是糖尿病和重度酗酒。类鼻疽主要表现为肺炎、泌尿生殖系统感染和菌血症。我们报告一例来自印度北部的类鼻疽病例,患者为一名56岁的糖尿病男性,表现为发热和黄疸。他的血培养伯克霍尔德菌呈阳性。肝脏受累表现为黄疸,血清胆红素值超过12mg/dL,肝酶高出十倍以上且无肝脓肿。他通过静脉注射抗生素治疗后病情好转,肝功能检查完全恢复正常。